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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Identification and classification of ion-channels across the tree of life: Insights into understudied CALHM channels

    Rahil Taujale, Sung Jin Park ... Natarajan Kannan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    • Inadequate
    1. Developmental Biology
    2. Physics of Living Systems

    Spiral-eyes: A soft active matter model of in vivo corneal epithelial cell migration

    Kaja Kostanjevec, Rastko Sknepnek ... Silke Henkes
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Developmental Biology

    Endothelial Slit2 guides the Robo1-positive sympathetic innervation during heart development

    Juanjuan Zhao, Susann Bruche ... Mathilda TM Mommersteeg
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Diversity and functional specialization of oyster immune cells uncovered by integrative single-cell level investigations

    Sebastien De La Forest Divonne, Juliette Pouzadoux ... Emmanuel Vignal
    Single-cell and functional analyses uncover distinct immune cell types, revealing specialized functions and deepening insight into invertebrate cellular immunity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy

    Liudmyla Arifova, Brian S MacTavish ... Douglas J Kojetin
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Physics of Living Systems
    2. Evolutionary Biology

    Magnetotactic Bacteria Optimally Navigate Natural Pore Networks

    Alexander P Petroff, Julia Hernandez ... Nina Radchenko-Hannafin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Information, certainty, and learning

    Justin A Harris, Charles R Gallistel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    • Solid
    1. Neuroscience

    Dynamics of striatal action selection and reinforcement learning

    Jack W Lindsey, Jeffrey Markowitz ... Ashok Litwin-Kumar
    A theory of striatal synaptic plasticity separates activity related to learning and action execution into non-interfering subspaces.
    1. Medicine

    Characterisation and comparison of semen microbiota and bacterial load in men with infertility, recurrent miscarriage, or proven fertility

    Shahriar Mowla, Linda Farahani ... Channa N Jayasena
    There are common seminal microbiome clusters in both healthy men and those with infertility and recurrent pregnancy loss, and some specific microbiota perturbations are associated with impaired semen quality.
    1. Neuroscience

    Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortex

    J Daniel Obray, Erik T Wilkes ... L Judson Chandler
    Adolescent alcohol exposure reduced basolateral amygdala-driven inhibition of pyramidal neurons projecting from the prefrontal cortex to the periaqueductal gray and increased inhibition of prefrontal parvalbumin interneurons.
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