1. Chromosomes and Gene Expression
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DNA Damage: Proteins pinpoint double strand breaks

  1. Michael M Cox  Is a corresponding author
  1. University of Wisconsin-Madison, United States
Cite this article as: eLife 2013;2:e01561 doi: 10.7554/eLife.01561
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1 figure


How double strand breaks occur during replication.

Many DNA repair processes generate transient single strand breaks in chromosomes. If a replication fork encounters such a break before it is repaired (top and middle), one arm of the replication fork separates to create a double strand break (bottom).

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