1. Structural Biology and Molecular Biophysics
  2. Computational and Systems Biology
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Cytoskeleton: Large-scale microtubule networks contract quite well

  1. Julio M Belmonte
  2. François Nédélec  Is a corresponding author
  1. European Molecular Biology Laboratory, Germany
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Cite this article as: eLife 2016;5:e14076 doi: 10.7554/eLife.14076
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Two mechanisms for contraction: buckling and end clustering.

Top: When two anti-parallel actin filaments are bridged by a myosin motor (blue) and a crosslink (green), their relative movement forces one filament to buckle, resulting in the contraction of the network. Bottom: Microtubule contraction seems to depend on the affinity of dynein motors (red) for the ends of the filaments. For a recent review on the topic of contraction, see Clark et al., 2014.

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