1. Microbiology and Infectious Disease
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Host-virus Interactions: Phylogenetic sleuthing reveals pair of paralogous genes

  1. Jamie E Henzy
  2. Welkin E Johnson  Is a corresponding author
  1. Boston College, United States
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Cite this article as: eLife 2016;5:e17224 doi: 10.7554/eLife.17224
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Figures

A yeast assay to discriminate between the antiviral proteins IFIT1 and IFIT1B.

IFIT1 and IFIT1B both inhibit the growth of budding yeast (Saccharomyces cerevisiae; top row, middle and right). Co-expressing human Cap1-methyltransferase (which converts cap0-mRNA to cap1-mRNA by adding a methyl group to the first ribose sugar; left) rescued yeast cells expressing IFIT1B (bottom row, right), but not yeast cells expressing IFIT1B (bottom row, middle). Daugherty et al. used this assay to study a wide range of IFIT1/IFIT1B homologs. IFIT: interferon-induced tetratricopeptide repeats.

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