The Cambrian explosion was a unique animal radiation ~540 million years ago that produced the full range of body plans across bilaterians. The genetic mechanisms underlying these events are unknown, leaving a fundamental question in evolutionary biology unanswered. Using large-scale comparative genomics and advanced orthology evaluation techniques, we identified 157 bilaterian-specific genes. They include the entire Nodal pathway, a key regulator of mesoderm development and left-right axis specification; components for nervous system development, including a suite of G protein-coupled receptors that control physiology and behaviour, the Robo-Slit midline repulsion system, and the neurotrophin signalling system; a high number of zinc finger transcription factors; and novel factors that previously escaped attention. Contradicting the current view, our study reveals that genes with bilaterian origin are robustly associated with key features in extant bilaterians, suggesting a causal relationship.
- Thomas Wiehe
- Kristen A Panfilio
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
- Patricia J Wittkopp, University of Michigan, United States
- Received: January 31, 2019
- Accepted: July 3, 2020
- Accepted Manuscript published: July 16, 2020 (version 1)
© 2020, Heger et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Natural light gradients within a habitat may have helped form new fly species that have differing preferences for light.
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