Dopamine role in learning and action inference
Abstract
This paper describes a framework for modelling dopamine function in the mammalian brain. It proposes that both learning and action planning involve processes minimizing prediction errors encoded by dopaminergic neurons. In this framework, dopaminergic neurons projecting to different parts of the striatum encode errors in predictions made by the corresponding systems within the basal ganglia. The dopaminergic neurons encode differences between rewards and expectations in the goal-directed system, and differences between the chosen and habitual actions in the habit system. These prediction errors trigger learning about rewards and habit formation, respectively. Additionally, dopaminergic neurons in the goal-directed system play a key role in action planning: They compute the difference between an available reward and the reward expected from the current motor plan, and they facilitate action planning until this difference diminishes. Presented models account for dopaminergic responses during movements, effects of dopamine depletion on behaviour, and make several experimental predictions.
Data availability
Matlab codes for all simulations described in the paper are available at MRC Brain Network Dynamics Unit Data Sharing Platform(https://data.mrc.ox.ac.uk/data-set/simulations-action-inference).
-
Simulations of action inferenceMRC Brain Network Dynamics Unit Data Sharing Platform.
Article and author information
Author details
Funding
Medical Research Council (MC_UU_12024/5)
- Rafal Bogacz
Medical Research Council (MC_UU_00003/1)
- Rafal Bogacz
Biotechnology and Biological Sciences Research Council (BB/S006338/1)
- Rafal Bogacz
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Copyright
© 2020, Bogacz
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 10,001
- views
-
- 1,011
- downloads
-
- 58
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.