Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience
- Brown University, United States
- Boston College, United States
Abstract
In cognitive neuroscience, computational modeling can formally adjudicate between theories and affords quantitative fits to behavioral/brain data. Pragmatically, however, the space of plausible generative models considered is dramatically limited by the set of models with known likelihood functions. For many models, the lack of a closed-form likelihood typically impedes Bayesian inference methods. As a result, standard models are evaluated for convenience, even when other models might be superior. Likelihood-free methods exist but are limited by their computational cost or their restriction to particular inference scenarios. Here, we propose neural networks that learn approximate likelihoods for arbitrary generative models, allowing fast posterior sampling with only a one-off cost for model simulations that is amortized for future inference. We show that these methods can accurately recover posterior parameter distributions for a variety of neurocognitive process models. We provide code allowing users to deploy these methods for arbitrary hierarchical model instantiations without further training.
Data availability
All code is provided freely and is available at the following links: https://github.com/lnccbrown/lans/tree/master/hddmnn-tutorial, https://github.com/lnccbrown/lans/tree/master/al-mlp and https://github.com/lnccbrown/lans/tree/master/al-cnn.
Article and author information
Author details
Lakshmi N Govindarajan
Funding
National Institute of Mental Health (P50 MH119467-01)
- Michael J Frank
National Institute of Mental Health (R01 MH084840-08A1)
- Michael J Frank
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Valentin Wyart, École normale supérieure, PSL University, INSERM, France
Version history
- Received: November 21, 2020
- Accepted: April 1, 2021
- Accepted Manuscript published: April 6, 2021 (version 1)
- Version of Record published: May 6, 2021 (version 2)
- Version of Record updated: May 21, 2021 (version 3)
Copyright
© 2021, Fengler et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience
eLife 10:e65074.
https://doi.org/10.7554/eLife.65074
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