1. Developmental Biology
  2. Stem Cells and Regenerative Medicine
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Regeneration: A matter of nerves

  1. Timothy J Duerr
  2. James R Monaghan  Is a corresponding author
  1. Department of Biology, Northeastern University, United States
Cite this article as: eLife 2021;10:e75629 doi: 10.7554/eLife.75629
1 figure


Limb regeneration in the axolotl salamander.

Previous studies suggest that nerves play a role in limb regeneration. Wells et al. hypothesized that larger animals have more nerves, and that blastemas from a smaller animal grafted onto a large animal would cause the new limb to grow to the same size as the animal’s existing limb. Large (top; pink) and small (bottom; pink) axolotls were grafted with blastemas from small (top; green) and large (bottom; green) individuals, respectively. Regardless of the size of the blastema they received, the animals grew limbs matching their body size, suggesting that the number of nerves could play a role in determining the size of the regenerate limb.

Image credit: The figure was generated using BioRender.

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