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A better understanding of the remarkable diversity, natural history and complex ecology of E. coli in the wild could shed new light on its biology and role in disease, and further expand its many uses as a model organism.

A better understanding of the natural history of model organisms will increase their value as model systems and also keep them at the forefront of research.

Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.

The yeast Saccharomyces cerevisiae has informed our understanding of molecular biology and genetics for decades, and learning more about its natural history could fuel a new era of functional and evolutionary studies of this classic model organism.

The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.

What if every creative endeavor had to go through Peer Review? Indira M Rama considers the possibility.

In science it is more important to recognize excellence in its many different forms than it is to identify a winner.

Reading and discussing classic papers can be an effective way of teaching graduate students how to learn the skills they will need for a career in research.

Ignoring the probability of species variation when reporting observations about biological processes leads to misinterpretation of the experimental data.

The Reproducibility Project: Cancer Biology will generate a high-quality dataset to explore questions about the reproducibility of research, and will make all data, analysis and other research materials openly available to the research community.