Rab10 and Rab4 bidirectionally regulate AMPA receptor trafficking and spine structural plasticity during long-term potentiation by exhibiting opposing and temporally distinct activity patterns in stimulated dendritic spines.
Membrane geometry switches protein condensate organization of postsynaptic density proteins by reducing crowding effects while maintaining specific binding, allowing targeted interactions to dominate over size-based exclusion.
To parse foreground and background sounds, the auditory cortex of humans and ferrets share a similar hierarchical organization, but the underlying computational mechanisms are fundamentally different.
Roger Eloiflin, Elena Pérez-Antón ... Brice Rotureau
A novel array of CRISPR-based SHERLOCK tests for RNA detection was developed for eco-epidemiological surveillance of human and animal African trypanosomes from Western Africa with domestic pigs as sentinels.
Veronica H Ryan, Sydney Lawton ... Michael Emmerson Ward
Protein, but not mRNA, levels of neurodegenerative disease-associated protein TDP-43 are decreased upon knockdown of BORC, a complex that is required for the anterograde transport of lysosomes.
Justin M Campbell, Rhiannon L Cowan ... Jon Timothy Willie
Firing rate analyses revealed neurons throughout the hippocampus, amygdala, orbitofrontal cortex, and anterior cingulate cortex in humans that exhibited heterogeneous responses to intracranial theta burst stimulation of the human brain.