Residual plasma from rapid routine clinical chemistry tubes enables cell-free DNA NGS-based analysis, providing an untapped, scalable, and accessible resource without specialized collection workflows.
RadD recognition by NKp46 converts Fusobacterium nucleatum from an immune-evasive pathogen into a trigger of natural killer cell-mediated tumor control in a context-dependent manner.
During convergent extension morphogenesis, non-canonical Wnt induces the signal transducer Dishevelled to transition from Vangl to Frizzled, a process that is inhibited by Prickle but facilitated by the co-receptor Ror.
An on-demand seizure model in chronically epileptic mice integrates reliability and etiological relevance, providing a mechanistically grounded, efficient platform for evaluating pharmacological interventions.
Chengcheng Fan, Alexander A Cohen ... Magnus AG Hoffmann
Bivalent EABR mRNA boosters broaden neutralizing responses to Omicron subvariants by promoting diverse receptor-binding domain epitope targeting, although antibody responses remain partially shaped by immune imprinting from prior vaccination.
Computer simulations reveal the structural basis for a selective mechanism of ion-channel inhibition that could guide future pharmacological developments against associated human health disorders.
The thermosensory neuron AFD unexpectedly modulates locomotion based on tactile experience through molecular and circuit mechanisms distinct from those underlying thermosensation.
