Browse our Research Articles

Page 10 of 1,497
    1. Neuroscience

    Tactile localization of the breast, areola, and nipple

    Katie H Long, Emily E Fitzgerald ... Charles M Greenspon
    The breast, despite its importance in sexual and affective touch, exhibits poor tactile localization and demonstrates a relationship between size and innervation density.
    1. Biochemistry and Chemical Biology

    Purified zymogens reveal mechanisms of snake venom metalloproteinase auto-activation

    Sophie Hall, Iara Aime Cardoso ... Christiane Schaffitzel
    A generic strategy for producing functional snake venom metalloproteinases opens the field to reproducible mechanistic studies and inhibitor discovery.
    1. Neuroscience

    Altered cognitive processes shape tactile perception in autism

    Ourania Semelidou, Mathilde Tortochot-Megne Fotso ... Andreas A Frick
    Altered tactile decision-making in autism reflects context-dependent weighting of sensory inputs and diminished integration of sensory history, enhancing low-salience discrimination while reducing category-based perceptual facilitation.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

    Conor J Howard, Nathan S Abell ... Diane E Dickel
    A comprehensive mutational scan of TYK2 identifies novel allosteric sites, elucidates functional drug-protein interactions, and links autoimmune disease protection to reduced TYK2 protein abundance.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cell size modulates ferroptosis susceptibility

    Evgeny Zatulovskiy, Magdalena B Murray ... Jan M Skotheim
    Cellular sensitivity to cell death stimuli depends on cell-size-dependent proteome changes - specifically, cell size can modulate ferroptosis susceptibility through changes in glutathione biosynthetic enzymes, ferritin, and cathepsin B concentrations.
    1. Cell Biology

    Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

    Xiaoning Gao, Wuyan Guo ... Jun Kang
    Non-covalent targeting of KEAP1 by capsaicin provides a reversible and safe NRF2 agonist for treating oxidative damage.
    1. Neuroscience

    Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque

    Richard Johnston, Matthew A Smith
    Arousal signals are present in the superior colliculus but appear to be organized in a way that they avoid directly triggering motor plans that lead to saccades.
    1. Microbiology and Infectious Disease

    Membrane binding controls the ATPase cycle and localization of MinD in Bacillus subtilis

    Helge Feddersen, Charlotte Dyckmans, Marc Bramkamp
    Dynamic relocalization of MinD in Bacillus subtilis arises from membrane binding of monomers and dimers with membrane-triggered ATP hydrolysis, suggesting MinE-like activators are unnecessary for Min system dynamics.
    1. Microbiology and Infectious Disease

    A macroevolution-inspired approach to reveal novel antibiotic resistance mechanisms

    Fernanda T Subtil, Teresa FG Machado ... Luiz Pedro S de Carvalho
    Using macroevolution, species not strains, uncovered important diversity in how mycobacteria respond to and resist antibiotics, revealing novel resistance determinants.
    1. Genetics and Genomics
    2. Neuroscience

    Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling

    Kasturi Biswas, Caroline Moore ... Michael M Francis
    Muscarinic cholinergic signaling links neural activity to organism‑wide transcriptional and proteostatic responses that protect against chronic oxidative stress.