Browse our Research Articles

Page 10 of 1,441
    1. Neuroscience

    Characterization of postsynaptic glutamate transporter functionality in the zebrafish retinal first synapse across different wavelengths

    Marco Garbelli, Stephanie Niklaus, Stephan CF Neuhauss
    Loss of the glutamate transporters EAAT5b and EAAT7 disrupts wavelength-specific visual processing and UV-dependent prey detection in zebrafish, revealing their key roles in modulating light integration and behaviorally relevant vision.
    1. Computational and Systems Biology
    2. Neuroscience

    Correlation detection as a stimulus computable account for audiovisual perception, causal inference, and saliency maps in mammals

    Cesare V Parise
    Optimal cue integration, Bayesian Causal Inference, spatial orienting, speech illusions and other key phenomena in audiovisual perception naturally emerge from the collective behavior of a population of Multisensory Correlation Detector.
    1. Cell Biology
    2. Developmental Biology

    Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in mouse pancreatic β cells

    Kai M Bracey, Margret A Fye ... Irina Kaverina
    Sub-membrane microtubule array, known to prevent excessive glucose-stimulated insulin secretion, depends on kinesin-1 KIF5B, which moves microtubules to both generate and remodel this array, potentially regulating the dosage of secretion.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

    Soumajit Dutta, Diwakar Shukla
    New psychoactive substances activate cannabinoid receptors using distinct ligand-receptor interactions.
    1. Biochemistry and Chemical Biology

    Insight into the bioactivity and action mode of betulin, a candidate aphicide from plant metabolite, against aphids

    Junxiu Wang, Matthana Klakong ... Hong Zhou
    The insecticidal activity of betulin, a plant-derived metabolite, against the peach aphid depends on specific targeting and inhibition of MpGABR.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Short heat shock factor A2 regulates heat resistance and growth balance in Arabidopsis

    Wanxia Chen, Jiaqi Zhao ... Xiaoting Qi
    Short heat shock factor variants prevent hyperactivation of thermotolerance through a noncanonical heat shock response, thereby balancing heat stress response and plant growth.
    1. Biochemistry and Chemical Biology

    Engineering NIR-sighted bacteria

    Stefanie SM Meier, Michael Hörzing ... Andreas Möglich
    Custom-tailored bathy-phytochromes control bacterial gene expression by near-infrared light while exhibiting minimal response to red light, thus unlocking innovative application scenarios.
    1. Neuroscience

    Relative timescale of channel voltage dependence and channel density regulation impacts assembly and recovery of activity

    Yugarshi Mondal, Ronald L Calabrese, Eve Marder
    Ion channel voltage-dependence alterations can shape intrinsic homeostatic plasticity, even if operating faster than other intrinsic regulatory processes—where timescale separation would suggest its influence should be negligible.
    1. Cell Biology

    Distinct functions of cardiac β-adrenergic receptors in the T-tubule vs. outer surface membrane

    George WP Madders, Marion Barthé ... Rodolphe Fischmeister
    A size exclusion strategy using PEGylation of isoprenaline allowed to demonstrate that cardiac β-adrenergic receptors located in the outer surface membrane control mainly cAMP/PKA in the cytosol while those located in the T-tubule membrane control cAMP/PKA in the nucleus.
    1. Developmental Biology
    2. Physics of Living Systems

    Migrating mesoderm cells self-organize into a dynamic meshwork structure during chick gastrulation

    Yukiko Nakaya, Mitsusuke Tarama ... Tatsuo Shibata
    A novel form of collective mesenchymal cell migration is identified during chick gastrulation, where a dynamic 3D meshwork supported by N-cadherin-mediated adhesion coordinates movement and enhances directional migration in the unconfined space between ectoderm and endoderm.