Harrison A Grier, Sohrab Salimian, Matthew T Kaufman
Mouse primary motor and somatosensory cortices contain detailed information about the many time-varying arm and paw joint angles during reaching and grasping, implying a 'low-level' role in controlling these movements.
Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8+ T cell immunity.
Muscle stem cells repurpose the tenogenic factor Scx to establish a muscle-specific transcriptional program that sustains stem cell expansion, migration, differentiation, fusion, self-renewal, and survival.
A multidisciplinary approach demonstrates that glycolysis orchestrates fungal morphogenesis and virulence by regulating the de novo biosynthesis of sulfur-containing amino acids, thereby establishing a novel metabolic paradigm.
Small-molecule mitochondrial transcription factor A modulators stabilize mtDNA, preventing cytosolic escape and suppressing cGAS-STING interferon signaling, while improving bioenergetics and fibrosis markers in disease models.
Mir195 enables Ebf1-deficient hematopoietic progenitor cells to mature into B cells, suggesting some miRNA can substitute for transcription factors in differentiation.
Upregulated expression of transcription factors promoting cone identity in late-stage retinal progenitors drives development of the cone-dominant retina of 13-lined ground squirrels.
The IL-17–Ly6G⁺ granulocyte axis is a key driver and correlate of tuberculosis pathology and represents a potential target for improving vaccine-induced protection and therapeutic outcomes.
