Browse our Research Articles

Page 10 of 1,477
    1. Neuroscience

    Visual experience shapes functional connectivity between occipital and non-visual networks

    Mengyu Tian, Xiang Xiao ... Marina Bedny
    At birth, infant visual cortex connectivity resembles that of blind adults, while lifetime visual experience enhances long-range functional connectivity between visual cortices, sensorimotor systems, and dampens connectivity with executive networks.
    1. Neuroscience

    Profiling presynaptic scaffolds using split-GFP reconstitution reveals cell-type-specific spatial configurations in the fly brain

    Hongyang Wu, Yoh Maekawa ... Hiromu Tanimoto
    Profiling endogenous Bruchpilot proteins in multiple cell types in mushroom bodies uncovered multilayered spatial configurations of active zones, from stereotyped intracellular distribution patterns to local arrangements of neighboring synapses.
    1. Neuroscience

    Formation of task representations and replay in mouse medial prefrontal cortex

    Hamed Shabani, Hannah Muysers ... Christian Leibold
    Longitudinal calcium imaging in the medial prefrontal cortex reveals the emergence of de novo task representations and reward-associated replay.
    1. Microbiology and Infectious Disease

    Mycobacterial metallophosphatase MmpE acts as a nucleomodulin to regulate host gene expression and promote intracellular survival

    Liu Chen, Baojie Duan ... Aizhen Guo
    Mycobacterium tuberculosis utilizes nucleomodulins to disrupt host inflammatory responses and lysosomal maturation, uncovering a novel strategy for immune evasion and intracellular survival.
    1. Neuroscience

    iGABASnFR2 is an improved genetically encoded protein sensor of GABA

    Ilya Kolb, Jeremy P Hasseman ... Glenn C Turner
    An improved genetically encoded GABA sensor enables the most effective direct optical measurement of inhibitory neurotransmission to date.
    1. Evolutionary Biology

    Earliest evidence of elephant butchery at Olduvai Gorge (Tanzania) reveals the evolutionary impact of early human megafaunal exploitation

    Manuel Dominguez-Rodrigo, Enrique Baquedano ... Audax Mabulla
    The discovery of the earliest direct evidence of systematic proboscidean butchery at Olduvai Gorge demonstrates that by 1.8 Ma early hominins had strategically integrated megafaunal exploitation into their subsistence systems.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration in human cancer cells

    Ravi Kumar, Simon Couly ... Ashish Lal
    Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

    Philip MM Ruppert, Aylin S Gueller ... Jan-Wilhelm Kornfeld
    Transcriptomic profiling on liver and adipose depots reveals tissue-specific and beige-fat–convergent responses to methionine restriction and cold, providing a high-quality resource to guide combinatorial lifestyle interventions for metabolic disease research.
    1. Developmental Biology
    2. Neuroscience

    The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

    Sen-Lin Lai, Chris Q Doe
    Fd4 is expressed in NB7-1 and new-born progeny where it activates terminal selector genes to produce lineage-specific neurons.
    1. Computational and Systems Biology
    2. Neuroscience

    Self-association enhances early attentional selection through automatic prioritization of socially salient signals

    Meike Scheller, Jan Tünnermann ... Jie Sui
    Self-related information automatically modulates early attentional selection into awareness through mechanisms distinct from physical salience, revealing an obligatory, individualized self-prioritization at the gateway to perception.