The Hippo pathway maintains the integrity of differentiated neurons by modulating microtubule stability, and reducing microtubule stability of fully developed neurons offers a potential strategy to delay neuronal aging.
Kaplan–Meier curves showed that extended adjuvant pyrotinib administered after trastuzumab-based adjuvant therapy provides a promising survival benefit in patients with high-risk HER2-positive breast cancer.
Ljiljana Mihajlovic, Bharat Ravi Iyengar ... Yolanda Schaerli
Experimental evolution of a duplicated gene increases mutational robustness relative to a single-copy gene but does not accelerate phenotypic evolution.
Rab10 deficiency unexpectedly inhibits neuropeptide secretion through two distinct effects on the endoplasmic reticulum (ER), disrupting ER-regulated intracellular Ca²⁺ dynamics and impairing protein synthesis.
Thomas A Bos, Elizaveta Polyakova ... Monique RM Jongbloed
Although methods to efficiently generate functional autonomic postganglionic neurons from human pluripotent stem cells largely mirror signaling cues during embryonic development, several in vivo signaling cues remain to be explored in vitro.
This enzymatic method enables highly specific and complete 1:1 protein conjugations with small molecules, solid supports, and other proteins, offering broad applicability across diverse biochemical and biotechnological applications.
Computational modelling suggests that the segmentation clock and the morphogenesis of the pre-somitic mesoderm exhibit developmental modularity, enabling the independent evolution of these processes and possibly contributing to the high evolvability of vertebrate segment number.
