Social clustering behaviors in Drosophila are closely tied to compensatory mechanisms for developmental traits and adaptive behavior plasticity, requiring early-life social experiences and the memory-encoding neuropeptide signaling pathway.
Angel D'Oliviera, Xuhang Dai ... Jeffrey S Mugridge
The SARS-CoV-2 main protease specifically cleaves a conserved sequence in the human tRNA modifying enzyme TRMT1, resulting in reduced tRNA binding and the complete loss of TRMT1-mediated tRNA methyltransferase activity.
Emily Delgouffe, Samuel Madureira Silva ... Ellen Goossens
Gender-affirming hormone therapy in trans women leads to a loss of mature characteristics in the spermatogonial stem cell niche, causes spermatogenic arrest, and triggers fibrotic processes.
Masroor Ahmad Paddar, Fulong Wang ... Vojo Deretic
Membrane atg8ylation but not canonical autophagy control retromer-dependent endosomal sorting of cargo, including glucose transporter GLUT1, of general import and of significance for control of tuberculosis.
Zigmunds Orlovskis, Archana Singh ... Saskia A Hogenhout
Phytoplasma effector SAP54 hijacks previously unknown MADS-box protein roles in plant-insect interactions by modulating plant biotic stress responses to male leafhoppers and facilitating female attraction and reproduction on male-exposed leaves.
Common mouse models of polycystic ovary syndrome (PCOS) have variable ability to recapitulate the increased GnRH pulse generator frequency thought to exist in women with PCOS.
Timothy J Abreo, Emma C Thompson ... Edward C Cooper
A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.
Electric signals produced by weakly electric gymnotiform fish, long seen as communication attempts, may also serve to localize conspecifics, revealing a distinct functional role.
