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As Caenorhabditis elegans shifts from reactive to increasingly proactive defensive strategies, nuanced changes in interaction between SEB-3 receptor and NLP-49 peptides regulate the transitions between defensive behaviors.

A camelid single-domain antibody potently and specifically inhibits pyruvate kinases from trypanosomatids.

Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.

Salt stress disrupts root-shoot growth coordination through SR3G, a negative regulator of salt tolerance, that affects shoot growth, root suberization, and sodium accumulation, revealing new targets for environmental resilience.

A novel mutant, ^R25CPTH, derived from a hypoparathyroidism patient, can form a dimer that activates PTH1R and enhances bone formation in female mice similar to PTH despite altered molecular properties.

Equations generalizing reward rate maximization are derived, explaining ostensible suboptimal behaviors, revealing time’s cost to comprise apportionment and opportunity costs, and identifying the misestimation in time apportionment as the actual error committed in temporal decision making by animals and humans.

Multimodal analysis of human cortical excitatory neurons reveals age-dependent differences.

Multi-omics analysis shows that preeclampsia-specific immune cell network was regulated by Folr2⁺Ccl7⁺Ccl8⁺C1qa⁺C1qb⁺C1qc⁺ pro-inflammatory macrophages, which can induce the CD8⁺ and Th17 memory T cells generation while inhibiting the gMDSCs production.

Cortex-wide projections onto primary sensory and motor areas display substantial interhemispheric symmetry in their areal input identity and are primarily feedback in nature due to dominant inputs from Layer 6.

Pharmacologically induced hypothermia elicits anticonvulsant, neuroprotective, and anti-inflammatory properties.