Browse our Research Articles

Page 119 of 1,380
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Modulation of biophysical properties of nucleocapsid protein in the mutant spectrum of SARS-CoV-2

    Ai Nguyen, Huaying Zhao ... Peter Schuck
    Exploration of the phenotype space corresponding to the sequence space of viable SARS-CoV-2 nucleocapsid protein species reveals significant diversity of biophysical characteristics, nonlocal mutation effects, and functional constraints.
    1. Neuroscience

    Neural interactions in the human frontal cortex dissociate reward and punishment learning

    Etienne Combrisson, Ruggero Basanisi ... Andrea Brovelli
    Reward and punishment learning is represented in partly overlapping regions of the brain while relying on specific intra- and inter-regional interactions.
    1. Neuroscience

    GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation

    Carlos Gonzalez-Islas, Zahraa Sabra ... Peter Wenner
    Chronic perturbations of spiking activity trigger compensatory changes in GABAergic synaptic strength, but not compensatory changes in AMPAergic synaptic strength.
    1. Epidemiology and Global Health

    Strong isolation by distance and evidence of population microstructure reflect ongoing Plasmodium falciparum transmission in Zanzibar

    Sean V Connelly, Nicholas F Brazeau ... Jeffrey A Bailey
    Parasite migration between mainland Tanzania and Zanzibar and ongoing transmission clusters within Zanzibar highlight the need for continued preventive measures to reduce malaria transmission in the archipelago.
    1. Neuroscience

    Convergence of inputs from the basal ganglia with layer 5 of motor cortex and cerebellum in mouse motor thalamus

    Kevin P Koster, S Murray Sherman
    A detailed physiological characterization of inputs to the motor thalamus adds nuance to the notion that information from the cerebellum and basal ganglia are segregated and provides a mechanism by which the basal ganglia can gate communication between cortical areas.
    1. Microbiology and Infectious Disease

    RNA polymerase III is involved in regulating Plasmodium falciparum virulence

    Gretchen Diffendall, Aurelie Claes ... Artur Scherf
    RNA polymerase III plays a crucial role in controlling virulence in response to environmental changes and provides a new molecular perspective into the development of asymptomatic malaria.
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    1. Cancer Biology

    FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation

    Chenxi Gao, Huaibin Ge ... Jing Hu
    Mice studies show that the 'just-right' balance optimal for BRAFV600E-induced cecal tumor formation can be achieved through FAK alteration.
    1. Genetics and Genomics
    2. Neuroscience

    The neuron-specific IIS/FOXO transcriptome in aged animals reveals regulatory mechanisms of cognitive aging

    Yifei Weng, Shiyi Zhou ... Coleen T Murphy
    Neuron-specific sequencing of aged wild-type, daf-2, and daf-16;daf-2 mutants revealed transcriptomic changes with age, and in longevity mutants, putative neuroprotective genes are upregulated, which are required for prolonged cognitive functions.
    1. Computational and Systems Biology

    Accurate prediction of CDR-H3 loop structures of antibodies with deep learning

    Hedi Chen, Xiaoyu Fan ... Boxue Tian
    A deep learning-based toolkit predicting the 3D structures of monoclonal antibodies and nanobodies outperforms other current computational methods.
    1. Immunology and Inflammation

    Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis

    Mariano Maio, Joaquina Barros ... Luciana Balboa
    A newly identified immunometabolic mechanism clarifies the aberrant trafficking of dendritic cells to lymph nodes in tuberculosis.