Browse our Research Articles

Page 54 of 1,403
    1. Neuroscience

    Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species

    Hans Martin Kjer, Mariam Andersson ... Tim B Dyrby
    Common principles of white matter microstructure and pathway organisation was revealed using diffusion MRI and x-ray synchrotron imaging across resolutions, and employing diffusion tensor, micro-tensor, multi-fiber, and structure tensor models.
    1. Neuroscience

    Adaptive chunking improves effective working memory capacity in a prefrontal cortex and basal ganglia circuit

    Aneri Soni, Michael J Frank
    This frontostriatal neural network model links the source of working memory capacity limitations to challenges in learning resource management, and mitigates this challenge by learning a 'chunking' strategy.
    1. Neuroscience

    An image-computable model of speeded decision-making

    Paul I Jaffe, Gustavo X Santiago-Reyes ... Russell A Poldrack
    Combining biologically-plausible neural network models of vision with traditional decision-making models enables a detailed characterization of how the visual system extracts representations that guide decisions from raw sensory inputs.
    1. Neuroscience

    Volume electron microscopy reveals unique laminar synaptic characteristics in the human entorhinal cortex

    Sergio Plaza-Alonso, Nicolas Cano-Astorga ... Lidia Alonso-Nanclares
    3D electron microscopy provides the first extensive quantitative ultrastructural dataset of synapses of the human entorhinal cortex.
    1. Structural Biology and Molecular Biophysics

    PROTAC-induced protein structural dynamics in targeted protein degradation

    Kingsley Y Wu, Ta I Hung, Chia-en A Chang
    Multi-level molecular modeling reveals how PROTAC-induced protein structural dynamics of degradation machinery complexes promote ubiquitination processes.
    1. Developmental Biology

    Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in early mouse embryos

    Yanlin Hou, Zhengwen Nie ... Hans R Scholer
    Although Oct4 is expressed earlier than Sox2 in mouse embryos, both of them begin to perform their role in activating pluripotency-related genes in the inner cell mass.
    1. Evolutionary Biology

    Dynamic simulations of feeding and respiration of the early Cambrian periderm-bearing cnidarian polyps

    Yiheng Zhang, Xing Wang ... Xiaoguang Yang
    Dynamic fluid-structure coupling method simulated the feeding and respiration patterns of Quadrapyrgites, revealing the relationship between the ancient medusozoans and modern jellyfish.
    1. Cell Biology

    Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors

    Weihua Wang, Junqiao Xing ... Zhangfeng Hu
    The discovery of X chromosome-associated protein 5 (Xap5)-mediated transcriptional rewiring of ciliary genes in animals reveals that this regulatory mechanism was conserved during evolution.
    1. Neuroscience

    Omissions of threat trigger subjective relief and prediction error-like signaling in the human reward and salience systems

    Anne L Willems, Lukas Van Oudenhove, Bram Vervliet
    The unexpected absence of danger is experienced as a pleasurable relief and activates reward-related brain regions in humans, highlighting an overlap in the processing of absent danger and rewards.
    1. Neuroscience

    Error prediction determines the coordinate system used for the representation of novel dynamics

    Raz Leib, David Franklin
    Motor memories represent dynamics in a minimum noise framework such that the execution of forces based on this representation minimizes the force distortion arising from neural noise, explaining the prior inconsistent force generalization results.