Table 2. | Modulation of anxiety and fear via distinct intrahippocampal circuits

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Modulation of anxiety and fear via distinct intrahippocampal circuits

Table 2.

Affiliation details

McLean Hospital, United States; Harvard Medical School, United States; The University of Tennessee Health Science Center, United States; Yale School of Medicine, United States; Russian Academy of Sciences, Russia; University of Zurich, Switzerland
Table 2.

Results of omnibus statistical tests of measured parameters in behavioral tests of anxiety and general locomotion.

DOI: http://dx.doi.org/10.7554/eLife.14120.013

1. Elevated Plus Maze (C57BL/6J)
Two-Way Factorial ANOVA; Factors: Genotype (between-subjects), Drug (between-subjects)
% Open Arm Time% Open Arm EntriesDistance Travelled
GenotypeF(3,75)=1.41p=0.25F(3,75)=0.13p=0.94F(3,75)=0.85 F(3, 69) = 1.11p=0.47
DrugF(1,75)=16.48p<0.001F(3,75)=2.33p=0.13F(3,75)=0.61p=0.44
Genotype x Drug InteractionF(3,63)=1.54p=0.21F(3,75)=1.47p=0.23F(3,75)=1.13p=0.34
1’. Elevated Plus Maze (129X1/SvJ)
Two-Way Factorial ANOVA; Factors: Genotype (between-subjects), Drug (between-subjects)
% Open Arm Time% Open Arm EntriesDistance Travelled
GenotypeF(3,55)=0.17p=0.92F(3,55)=1.59p=0.20F(3,55)=1.17p=0.33
DrugF(1,55)=11.49P=0.001F(1,55)=3.4649p=0.07F(1,55)=1.28p=0.29
Genotype x Drug InteractionF(3,55)=2.28p=0.09F(3,55)=0.50p=0.69F(3,55)=0.82p=0.49
2. Light / Dark Box
Two-Way Factorial ANOVA; Factors: Genotype (between-subjects), Drug (between-subjects)
% Time in LightEntries to Light
GenotypeF(3,73)=5.03p=0.003F(3,73)=0.84p=0.48
Drug(F(1,73)=26.00p<0.001F(1,73)=1.45p=0.23
Genotype x Drug InteractionF(3,73)=5.53p=0.002F(3,73)=2.17p=0.09
3. Open Field
Two-Way Factorial ANOVA; Factors: Genotype (between-subjects), Drug (between-subjects)
Distance Travelled
GenotypeF(3,56)=1.78p=0.16
DrugF(1,56)=0.04p=0.84
Genotype x Drug InteractionF(3,56)=0.43p=0.73