2,218 results found
    1. Ecology
    2. Neuroscience

    Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish

    Diogo Ribeiro, Ana Rita Nunes ... Rui F Oliveira
    Individual social behavior results from the interaction between the individuals own oxytocin receptor genotype and the oxytocin receptor genotypes of other individuals present in its social environment.
    1. Genetics and Genomics
    2. Neuroscience

    Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression

    Hyojin Kim, Eric B Gao ... Benjamin D Philpot
    Normalizing Tcf4 expression during early postnatal development improves behavioral outcomes in Pitt-Hopkins syndrome (PTHS) model mice, suggesting that genetic therapies are feasible in individuals with PTHS.
    1. Genetics and Genomics
    2. Neuroscience

    The structure of behavioral variation within a genotype

    Zachary Werkhoven, Alyssa Bravin ... Benjamin L de Bivort
    Multidimensional analysis of data from high-throughput behavioral assays reveals many independent axes of behavioral variation among inbred animals reared in the same environment.
    1. Neuroscience

    Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

    Andrea Merseburg, Jacquelin Kasemir ... Bina Santoro
    Two genetic mouse models for HCN1-linked developmental epileptic encephalopathy display distinct biophysical changes in HCN1 ion channel properties but similar worsening of seizures in response to antiepileptic drugs, thereby recapitulating key features of the human disease.
    1. Computational and Systems Biology
    2. Neuroscience

    Sex differences in learning from exploration

    Cathy S Chen, Evan Knep ... Nicola M Grissom
    A new computational analysis of decision making in mice shows sex biases in value-updating while exploring unknown options, with male mice tending to explore longer than females due to updating values more slowly.
    1. Ecology
    2. Neuroscience
    Silhouette of a zebra finch on a blue background.

    The Natural History of Model Organisms: Neurogenomic insights into the behavioral and vocal development of the zebra finch

    Mark E Hauber, Matthew IM Louder, Simon C Griffith
    The genetic and behavioral diversity of the zebra finch, both in the wild and in captivity, make it well-suited for neuroethological studies of vocal learning, culture, and social bonding.
    1. Neuroscience

    Inhibitory peptidergic modulation of C. elegans serotonin neurons is gated by T-type calcium channels

    Kara E Zang, Elver Ho, Niels Ringstad
    Genetic analysis of how neuropeptides control C. elegans reproductive behavior shows how T-type calcium channels engage and disengage target neurons from these critical regulators of neural circuits and behavior.
    1. Neuroscience

    MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function

    Sameer S Bajikar, Ashley G Anderson ... Huda Y Zoghbi
    Integrated analysis of transcriptional profiles from mice carrying distinct Mecp2 mutant alleles revealed that MeCP2 regulates Gdf11 expression in the brain, and that Gdf11 is a dosage-sensitive gene whose levels impact neuronal function and animal behavior.
    1. Computational and Systems Biology
    2. Neuroscience

    Action detection using a neural network elucidates the genetics of mouse grooming behavior

    Brian Q Geuther, Asaf Peer ... Vivek Kumar
    A machine learning method for action detection is developed and applied toward mouse grooming behavior.
    1. Genetics and Genomics

    Deterministic Genetic Barcoding for Multiplexed Behavioral and Single-Cell Transcriptomic Studies

    Jorge Blanco Mendana, Margaret Donovan ... Daryl M. Gohl

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