Individual social behavior results from the interaction between the individuals own oxytocin receptor genotype and the oxytocin receptor genotypes of other individuals present in its social environment.
Normalizing Tcf4 expression during early postnatal development improves behavioral outcomes in Pitt-Hopkins syndrome (PTHS) model mice, suggesting that genetic therapies are feasible in individuals with PTHS.
Zachary Werkhoven, Alyssa Bravin ... Benjamin L de Bivort
Multidimensional analysis of data from high-throughput behavioral assays reveals many independent axes of behavioral variation among inbred animals reared in the same environment.
Andrea Merseburg, Jacquelin Kasemir ... Bina Santoro
Two genetic mouse models for HCN1-linked developmental epileptic encephalopathy display distinct biophysical changes in HCN1 ion channel properties but similar worsening of seizures in response to antiepileptic drugs, thereby recapitulating key features of the human disease.
A new computational analysis of decision making in mice shows sex biases in value-updating while exploring unknown options, with male mice tending to explore longer than females due to updating values more slowly.
Mark E Hauber, Matthew IM Louder, Simon C Griffith
The genetic and behavioral diversity of the zebra finch, both in the wild and in captivity, make it well-suited for neuroethological studies of vocal learning, culture, and social bonding.
Genetic analysis of how neuropeptides control C. elegans reproductive behavior shows how T-type calcium channels engage and disengage target neurons from these critical regulators of neural circuits and behavior.
Sameer S Bajikar, Ashley G Anderson ... Huda Y Zoghbi
Integrated analysis of transcriptional profiles from mice carrying distinct Mecp2 mutant alleles revealed that MeCP2 regulates Gdf11 expression in the brain, and that Gdf11 is a dosage-sensitive gene whose levels impact neuronal function and animal behavior.