A retinal gene regulatory network prevents the formation of alternative cell fates from non-stochastic retinal progenitor cells.

The transition from a restrictive patterning mechanism to one sensitive to a variety of environmental cues in NOTCH-mediated angiogenesis offers crucial insights into vascularization in damaged organs and cancer therapy.

The transcriptomes of individual cells of the 1- to 102-cell stages in Caenorhabditis elegans embryogenesis are identified along with 119 embryonic cell states during cell fate specification, including ‘equivalence-group’ cell identities.

Highly reproducible and efficient human primordial germ cell differentiation was achieved through geometric confinement, which enabled quantitative dissection of the cell signaling driving this differentiation, revealing a major role of Wnt signaling is indirect by inducing Nodal signaling.

Single-cell RNA sequencing resolves inter- and intra-population heterogeneity, identifies rare cell types, and reconstructs specification trajectories during early neurogenesis of the mouse cerebellum.

ATAC-seq, CRISPR/Cas9 mutagenesis, reporter and gene expression assays revealed dynamic chromatin accessibility profiles governing differential gene expression during heart vs. pharyngeal muscle fate choices in the powerful chordate model Ciona.

During mouse preimplantation development, the complete loss of actomyosin contractility abolishes cytokinesis but not apico-basal polarisation, lineage specification, or fluid accumulation, which are the critical steps to the formation of the blastocyst.

Seastar larvae can regenerate their nervous system by specifying cells to express the gene sox2 to enter neural progenitor states that then follow embryonic gene regulatory modes to form new neurons.

A genetic framework that balances the numbers of multipotent precursors and differentiated cells in the developing airways of Drosophila is presented.

PRDM13, a transcriptional repressor, antagonizes activity of basic-helix-loop-helix transcriptional activators and protects the developing spinal cord from aberrant expression of ventral-restricted cell-type regulators to generate the correct composition of neurons in the dorsal spinal cord.