151 results found
    1. Microbiology and Infectious Disease

    High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy

    Claudia A Vera-Arias, Aurel Holzschuh ... Cristian Koepfli
    A novel high-throughput method for Plasmodium falciparum genotyping will enable malaria control programs to make informed decisions about the best tool to use for the diagnosis of malaria.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cell-free DNA as a potential biomarker of differentiation and toxicity in cardiac organoids

    Brian Silver, Kevin Gerrish, Erik Tokar
    Cardiac organoids have potential as a tool used for identifying cell-free DNA as biomarkers for toxicity and severity of exposure outcomes.
    1. Ecology
    2. Microbiology and Infectious Disease

    Mapping microbial ecosystems and spoilage-gene flow in breweries highlights patterns of contamination and resistance

    Nicholas A Bokulich, Jordyn Bergsveinson ... David A Mills
    Mapping microbial landscapes in indoor environments can predict how contaminants and spoilage resistance genes propagate within food-production environments, yielding novel insight for controlling spoilage.
    1. Cell Biology

    A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response

    James P Held, Gaomin Feng ... Maulik R Patel
    A key role for RNAs in sensing and mounting a response to mitochondrial stress.
    1. Cancer Biology

    Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

    Lan-Feng Dong, Jaromira Kovarova ... Jiri Neuzil
    A genetic approach documents that mitochondrial DNA moves from donor cells to recipient mtDNA-depleted cells in whole mitochondria and that this restores mitochondrial respiration and the capacity of the cells to form tumours.
    1. Stem Cells and Regenerative Medicine

    Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells

    Matias I Autio, Efthymios Motakis ... Roger SY Foo
    Depiction of novel human genomic safe harbour loci that have been validated in vitro for safety and stable expression in human embryonic stem cells and cell types from all the three germ lineages.
    1. Cancer Biology

    The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

    James D Joseph, Beatrice Darimont ... Jeffrey H Hager
    GDC-0810 is a novel, orally bioavailable SERD that exhibits robust pre-clinical activity in models of ER+ breast cancer, including models of tamoxifen resistance, and those that express the ERα mutations, ER.Y537S and ER.D538G.
    1. Genetics and Genomics

    Mitochondrial genomes of Pleistocene megafauna retrieved from recent sediment layers of two Siberian lakes

    Peter Andreas Seeber, Laura Batke ... Laura S Epp
    Abundant mitochondrial DNA of long-extinct large mammals in recent sediment of Siberian lakes suggests complex taphonomic redistribution.
    1. Microbiology and Infectious Disease

    Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

    Wannaporn Ittiprasert, Victoria H Mann ... Paul J Brindley
    Gene knock-out of the omega-1 ribonuclease of Schistosoma mansoni eggs resulted in immunologically impaired phenotype, showcasing the novel application of CRISPR/Cas9 genome editing and utility for functional genomics in schistosomes.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations

    Nir Drayman, Parthiv Patel ... Savaş Tay
    Single-cell analyses of cells infected by Herpes Simplex Virus 1 revealed extreme heterogeneity among infected cells, including the robust activation of developmental gene programs in highly infected cells.

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