15 results found
    1. Neuroscience

    Probing the functional impact of sub-retinal prosthesis

    Sébastien Roux, Frédéric Matonti ... Frédéric Chavane
    Existing artificial retinas produce distorted and imprecise activation of the visual system, but reverse engineering promises to refine the induced activation patterns.
    1. Cell Biology

    The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation

    Rengasayee Veeraraghavan, Gregory S Hoeker ... Robert G Gourdie
    Structural and functional investigations identify a structural unit for ephaptic coupling in the heart, and provide the mechanistic basis for a novel strategy for the treatment of arrhythmias.
    1. Neuroscience

    Rapid categorization of natural face images in the infant right hemisphere

    Adélaïde de Heering, Bruno Rossion
    Diverse photographs of human faces against their natural background trigger a specific electrical response in the right hemisphere of the brain in infants aged 4–6 months.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A bacteriophage endolysin that eliminates intracellular streptococci

    Yang Shen, Marilia Barros ... Daniel C Nelson
    Unlike other similar enzymes, the antimicrobial enzyme PlyC can interact with and translocate eukaryotic membranes, and then lyse and kill intracellular bacteria.
    1. Neuroscience

    Polyglycerol-opioid conjugate produces analgesia devoid of side effects

    Sara González-Rodríguez, Mohiuddin A Quadir ... Christoph Stein
    A novel opioid formulation producing analgesia similar to conventional opioids without permeation of blood-brain or intestinal barriers, thus precluding sedation, constipation and respiratory depression.
    1. Cell Biology

    Magnetic resonance measurements of cellular and sub-cellular membrane structures in live and fixed neural tissue

    Nathan H Williamson, Rea Ravin ... Peter J Basser
    Low-field single-sided magnetic resonance diffusion methods detect and measure permeability of sub-micron compartments which likely include cell processes, organelles, and cellular vesicles within ex vivo mouse spinal cords.
    1. Neuroscience

    Neural effects of continuous theta-burst stimulation in macaque parietal neurons

    Maria C Romero, Lara Merken ... Marco Davare
    Electrophysiological recordings in awake behaving monkeys show the first evidence of the effect of continuous theta-burst stimulation, a widely used repetitive transcranial magnetic stimulation protocol, at the level of single neurons.
    1. Neuroscience

    Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease

    Osman Shabir, Ben Pendry ... Jason Berwick
    Mice modelling atherosclerosis show neurovascular breakdown in the cortex compared to healthy controls, and inducing atherosclerosis in mice modelling Alzheimer's disease increases the number of amyloid plaques in the hippocampus.
    1. Cancer Biology

    IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1

    Ning Dai, Fei Ji ... Joseph Avruch
    The IGF2 mRNA binding protein-2/IMP2, overexpressed in many common cancers, drives cancer cell proliferation by increasing the abundance of IGF2 and the oncogene HMGA1, which controls a network of effectors that enhance IGF2 action.
    1. Neuroscience

    Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling

    Bob Bramson, Hanneke EM den Ouden ... Karin Roelofs
    Non-invasive manipulation of endogenously coupled neural rhythms enhances human control of social-emotional actions.

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