230 results found
    1. Cell Biology

    NuMA recruits dynein activity to microtubule minus-ends at mitosis

    Christina L Hueschen, Samuel J Kenny ... Sophie Dumont
    At mitosis, NuMA recruits dynein-dynactin to microtubule minus-ends, enabling robust microtubule clustering and the emergence of spindle poles.
    1. Cell Biology
    2. Neuroscience

    The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites

    Jana Dorfman Marcette, Jessica Jie Chen, Michael L Nonet
    The minus-ends of microtubules have been implicated as part of a damage sensor to initiate remodeling of nerve cells.
    1. Cell Biology
    2. Computational and Systems Biology

    Remote control of microtubule plus-end dynamics and function from the minus-end

    Xiuzhen Chen, Lukas A Widmer ... Yves Barral
    A mechanism for yeast centrosomes to differentiate the microtubule cytoskeleton.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Interface-acting nucleotide controls polymerization dynamics at microtubule plus- and minus-ends

    Lauren A McCormick, Joseph M Cleary ... Luke M Rice
    Comparative measurements and simulations of microtubule plus and minus end growth with mixed nucleotides demonstrate that nucleotide acts across a tubulin:tubulin interface to influence microtubule stability and dynamics.
    1. Cell Biology

    Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons

    Urko del Castillo, Michael Winding ... Vladimir I Gelfand
    Cortical dynein organizes unipolar microtubule arrays in Drosophila axons by expelling minus-end-out microtubules.
    1. Cell Biology

    Reconstitution of dynein transport to the microtubule plus end by kinesin

    Anthony J Roberts, Brian S Goodman, Samara L Reck-Peterson
    In vitro reconstitution reveals how a system of molecules works together to transport the motor protein dynein to the start of its track.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains

    Marvin E Tanenbaum, Ronald D Vale, Richard J McKenney
    The motor domains of dynein are sufficient to crosslink microtubules and slide them antiparallel to each other.
    1. Cell Biology
    2. Neuroscience

    PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons

    Claire E Richardson, Kerri A Spilker ... Kang Shen
    The protein PTRN-1 anchors microtubules in neuronal branches to promote proper neuron morphology and function in Caenorhabditis elegans.
    1. Computational and Systems Biology

    Active contraction of microtubule networks

    Peter J Foster, Sebastian Fürthauer ... Daniel J Needleman
    Microtubule networks in frog egg extracts can spontaneously contract in a manner that can be quantitatively described by an active fluid model.
    1. Cell Biology
    2. Developmental Biology

    NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans

    Shaohe Wang, Di Wu ... Karen Oegema
    The C. elegans ninein homolog NOCA-1 is important for the assembly of non-centrosomal microtubule arrays required for embryo production, nuclear positioning and larval development.

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