1,606 results found
    1. Cell Biology
    2. Physics of Living Systems

    Self-organization of kinetochore-fibers in human mitotic spindles

    William Conway, Robert Kiewisz ... Daniel J Needleman
    A biophysical model in which kinetochore microtubules nucleate at kinetochores and growth polward along nematic streamlines quantitatively explains kinetochore microtubule lengths, orientations, and spatially varying dynamics in metaphase human spindles.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

    Heidi Hehnly, David Canton ... John D Scott
    A protein kinase complex that is important for cell division is lost in testicular seminoma, which is a common cancer in men.
    1. Physics of Living Systems
    2. Cell Biology

    27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells

    Lei Zhang, Yubin Hou ... Xin Zhang
    An ultra-high static magnetic field changes mitotic spindle orientation in cells by exerting magnetic torques on both microtubules and chromosomes.
    1. Cell Biology
    2. Developmental Biology

    Optogenetic dissection of mitotic spindle positioning in vivo

    Lars-Eric Fielmich, Ruben Schmidt ... Sander van den Heuvel
    New germline gene expression, knockout, and optogenetic tools reveal essential roles for Gα-GPR-1,2/Pins as a regulatable membrane anchor and LIN-5/NuMA as an activator of cortical dynein in mitotic spindle positioning.
    1. Cell Biology
    2. Developmental Biology

    Mitotic spindle scaling during Xenopus development by kif2a and importin α

    Jeremy D Wilbur, Rebecca Heald
    An interaction between two proteins enables the spindle—the structure that segregates chromosome pairs during mitosis—to change size as cells divide.
    1. Cell Biology

    Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes

    KC Farrell, Jennifer T Wang, Tim Stearns
    Centrosomes in mammalian cells are required for timely completion of mitosis and in their absence the spindle assembly checkpoint is required to delay mitosis and allow assembly of a functional spindle.
    1. Cell Biology
    2. Computational and Systems Biology

    Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

    Christopher Edelmaier, Adam R Lamson ... Meredith D Betterton
    A computational model of fission yeast mitosis can interrogate mechanisms required for successful mitosis, the origin of spindle length fluctuations, and spindle force balance during assembly.
    1. Cell Biology

    The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle

    Faye M Nixon, Cristina Gutiérrez-Caballero ... Stephen J Royle
    Microtubules of mitotic spindle fibers are positioned and held together by a meshwork of multipolar connectors.
    1. Cell Biology
    2. Developmental Biology

    NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures

    Lindsey Seldin, Andrew Muroyama, Terry Lechler
    A newly identified microtubule binding activity of NuMA is required for orienting the mitotic spindle.
    1. Cell Biology
    2. Evolutionary Biology

    Evolution of an ancient protein function involved in organized multicellularity in animals

    Douglas P Anderson, Dustin S Whitney ... Kenneth E Prehoda
    Experimentally reconstructing the evolution of the molecular complex that animals use to orient the mitotic spindle establishes a simple genetic and physical mechanism for the emergence of a function essential for multicellularity.

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