37 results found
    1. Developmental Biology
    2. Neuroscience

    Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

    Andreas Zembrzycki, Adam M Stocker ... Dennis DM O'Leary
    Primary and higher order visual area dimensions in the neocortex are determined by the same genetic mechanisms during development which in turn also control the proportionate scaling between them.
    1. Developmental Biology

    FGF8-mediated gene regulation affects regional identity in human cerebral organoids

    Michele Bertacchi, Gwendoline Maharaux ... Michèle Studer
    A novel 2D-to-3D human brain organoid protocol reveals the pivotal role of FGF8 signaling in driving regional patterning and cellular diversity, while also modulating genes crucial for both normal and pathological neural development.
    1. Developmental Biology
    2. Neuroscience

    Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex

    Kawssar Harb, Melanie Richter ... Kent Duncan
    RNA-binding proteins use both translational activation and repression of key molecular determinants to post-mitotically sculpt the identity and connectivity of developing mouse neocortex in an area-specific manner.
    1. Developmental Biology

    LIS1 determines cleavage plane positioning by regulating actomyosin-mediated cell membrane contractility

    Hyang Mi Moon, Simon Hippenmeyer ... Anthony Wynshaw-Boris
    Novel insights into LIS1-dependent regulation of cell membrane contractility and cleavage axis specification identify a key molecular network regulating mitoses of neural progenitors and somatic cells during development.
    1. Developmental Biology
    2. Neuroscience

    Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF

    Haruka Sato, Jun Hatakeyama ... Kenji Shimamura
    VGF was identified as a factor secreted from thalamocortical axons essential for the cytoarchitectonic features of neocortical layer 4 in the sensory areas in mice.
    1. Developmental Biology

    A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development

    Kerstin Hasenpusch-Theil, Christine Laclef ... Thomas Theil
    Primary-cilia-mediated processing of the Gli3 transcription factor enables the formation of subtypes of projection neurons in appropriate numbers during the development of the cerebral cortex.
    1. Developmental Biology
    2. Neuroscience

    Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma

    Odessa R Yabut, Jessica Arela ... Samuel J Pleasure
    Mice with Suppressor of Fused mutations have aberrant cerebellar granule cell proliferation accompanied by ectopic expression of an FGF ligand, also expressed in infantile medulloblastoma patients.
    1. Neuroscience

    Common cell type nomenclature for the mammalian brain

    Jeremy A Miller, Nathan W Gouwens ... Amy Bernard
    A new nomenclature convention for mammalian cell types utilizing shared taxonomies and quantitative cell features is applied to high-quality, open data from the mouse and human brain.
    1. Neuroscience

    Single-cell transcriptomic evidence for dense intracortical neuropeptide networks

    Stephen J Smith, Uygar Sümbül ... Michael Hawrylycz
    Single-cell mRNA sequencing data from mouse neocortex expose evidence for peptidergic neuromodulation networks that locally interconnect every cortical neuron.
    1. Neuroscience

    PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice

    Achira Roy, Rory M Murphy ... Kathleen J Millen
    Embryonic PI3K-Yap activity regulates apical adhesion and proliferation of neural progenitors lining the lateral ventricular surface, to maintain the smooth, non-folded mouse brain and to prevent developmental hydrocephalus.

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