Parenchymal astrocytes are quiescent neural stem cells whose neurogenic potential can be unleashed by targeted manipulations guided by single-cell RNA sequencing data.

Single molecule mRNA imaging uncovers post-transcriptional regulation of myc mRNA, via a cell-intrinsic mechanism allowing individualised control of neural stem cell proliferation during Drosophila brain development.

Kruppel-like factor 9 (Klf9) is a transcriptional regulator of neural stem cell expansion in the adult hippocampus.

Developing long bones contain distinct mesenchymal stem-cell populations derived from mesoderm and neural crest, which have specialized functions in skeleton formation and the establishment of the hematopoietic stem-cell niche, respectively.

During axolotl spinal cord regeneration adult neural stem cells reactivate an embryonic neuroepithelial cell-like gene program that implements planar cell polarity to orient cell divisions, coupling polarized spinal cord growth with stem cell self-renewal.

The Drosophila equivalent of the human protein Mixed Lineage Leukemia 1n enables neural stem cells to generate neural progenitors through the fly equivalent of the human transcription factor Sp8, thereby contributing to an increased number and diversity of cell types during brain development.

Stem-cell-specific transcriptional repressors fine-tune levels of stemness gene transcripts in asymmetrically dividing neural stem cells by depositing low levels of repressive histone marks at these loci allowing progeny to rapidly initiate differentiation.

Sequentially expressed temporal transcription factors in neural stem cells during early development determine which progeny can undergo malignant transformation upon dedifferentiation.

SIRT1, a cellular metabolic sensor, transcriptionally promotes sphingomyelin degradation in embryonic stem cells, which in turn modulates their membrane fluidity and neural differentiation.

A physical niche for neural stem cells is generated by the induction of the immediate skin epithelium, a process triggered by the arrival of neural precursors during sensory organ formation in medaka.