Jack Alfred Bryant, Faye C Morris ... Ian R Henderson
Analysis of the E. coli protein DolP reveals the first dual BON-domain structure and identifies phospholipid binding as a new mechanism for protein localisation to the outer membrane division site.
The asymmetric combination of saturated and polyunsaturated acyl chains in phospholipids as typically observed in synapses makes membranes prone to deformation and fission without compromising their impermeability.
LPCAT3 incorporates arachidonic acid into membrane phospholipids, which promotes lipoprotein assembly by enabling triacylgylcerols to cluster in the membrane.
The amino acids that are necessary for phospholipid scrambling by ANO6/TMEM16F can, via domain swapping, confer scrambling activity to the chloride ion channel ANO1 that normally does not scramble phospholipids.
Nicolas Coudray, Georgia L Isom ... Damian C Ekiert
Structure of MlaFEDB ABC transporter with substrate bound in the outward-open pocket of MlaE provides mechanistic insights into lipid transport within the Gram-negative bacterial cell envelope.
ABHD16A is a phospholipid-modifying endoplasmic reticulum (ER) membrane protein required for both mitochondrial fission and fusion machinery recruitment to ER-associated mitochondrial constrictions.
Behavioral, lipidomic, and genetic analyses of adult Drosophila on a chronic high-sugar regime identified that fat body activity of a phospholipid biosynthesis enzyme, Pect, regulates insulin sensitivity and hunger response.
Acyloxyacyl hydrolase, the host lipase that detoxifies bacterial lipopolysaccharides, also deacylates oxidized phospholipids, preventing inflammasome activation in macrophages in vitro and ameliorating acute lung injury in vivo.
Florian Bleffert, Joachim Granzin ... Filip Kovacic
Membrane homeostasis in bacteria relies on the controlled degradation of endogenous phospholipids by intracellular phospholipases A, however their structures and catalytic mechanism are still poorly understood.
Signaling by TAM receptor tyrosine kinases requires the coincident engagement of a TAM ligand with both its receptor and the phospholipid phosphatidylserine.