The analysis of injury-reactivated tectal radial glia in zebrafish reveals a stochastic cell-cycle entry and cell-state-dependent regulation of the balance between neurogenesis and gliogenesis.
The work uncovers a muscle-epidermis-glia signaling axis, modulated by protease mig-17 and the basement membrane, that regulates synaptic allometry during growth in Caenorhabditis elegans.
Hedgehog signaling plays a role in regulating glia gene expression in planarians, pointing to a candidate ancestral and broadly used role for the Hedgehog pathway.
The appearance of NG2+ glial cells in the dorsal telencephalon of the embryo coincides with the establishment of the brain blood vessel network in mice.
Prion-like transfer of mutant huntingtin aggregates from presynaptic to postsynaptic neurons is enhanced by neuronal silencing and requires passage through the cytoplasm of Draper-expressing phagocytic glia in adult Drosophila brains.
Müller glia cells in the medaka (Oryzias latipes) retina act as lineage restricted progenitors which only regenerate photoreceptors but can be activated to perform as potent stem cells using Sox2.
Deposition of mutant oncohistones by alternative nucleosome assembly pathways results in dramatic local differences in histone methylation in pediatric diffuse midline gliomas.