573 results found
    1. Stem Cells and Regenerative Medicine
    2. Genetics and Genomics

    A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics

    Irene Gallego Romero, Bryan J Pavlovic ... Yoav Gilad
    A panel of chimpanzee induced pluripotent stem cells (iPSCs) will help realise the potential of iPSCs in primate studies, and in combination with genomic technologies, transform studies of comparative evolution.
    1. Stem Cells and Regenerative Medicine

    Complete suspension culture of human induced pluripotent stem cells supplemented with suppressors of spontaneous differentiation

    Mami Matsuo-Takasaki, Sho Kambayashi ... Yohei Hayashi
    Adding suppressors of spontaneous differentiation enables precise control of human induced pluripotent stem cell (hiPSC) status in suspension culture conditions and leads to scalable and automated cell therapy using hiPSCs.
    1. Stem Cells and Regenerative Medicine

    Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes

    Francis Grafton, Jaclyn Ho ... Mohammad Ali Mandegar
    Deep learning combined with induced pluripotent stem cell technology is an effective method to interrogate cellular phenotypes and predict patterns of cardiotoxicity in vitro.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Efficient generation of marmoset primordial germ cell-like cells using induced pluripotent stem cells

    Yasunari Seita, Keren Cheng ... Kotaro Sasaki
    In vitro model of germline specification in marmosets established by directed differentiation of induced pluripotent stem cells, which transcriptionally resemble pre-migratory primordial germ cells in vivo.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells

    Francesca Stillitano, Jens Hansen ... Jean-Sébastien Hulot
    A genetically diverse panel of subject-specific induced pluripotent stem cells models the in vitro susceptibility of cardiac cells to develop a cardiotoxic drug response.
    1. Genetics and Genomics

    Population-scale proteome variation in human induced pluripotent stem cells

    Bogdan Andrei Mirauta, Daniel D Seaton ... Angus I Lamond
    Protein abundance changes across human-induced pluripotent stem cell lines reflect genetic variation across donors, with underlying mechanisms including modulation of RNA expression and modification of protein-coding sequences.
    1. Microbiology and Infectious Disease

    Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient

    Yuki Tatekoshi, Chunlei Chen ... Hossein Ardehali
    A calcium transient measurement system utilizing human induced pluripotent stem cell-derived cardiomyocytes reveals the detrimental impact of inflammatory cytokines on cardiomyocyte relaxation and displays the potential of drugs to reverse these defects.
    1. Stem Cells and Regenerative Medicine

    Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state

    Yixuan Wang, Chengchen Zhao ... Shaorong Gao
    During reprogramming of human fibroblasts to naïve iPSCs there is transient reactivation of transcripts with the characteristics of 8-cell-stage-embryos.
    1. Stem Cells and Regenerative Medicine

    A versatile high-throughput assay based on 3D ring-shaped cardiac tissues generated from human induced pluripotent stem cell-derived cardiomyocytes

    Magali Seguret, Patricia Davidson ... Jean-Sébastien Hulot
    A novel hydrogel-based platform uses a limited number of cells for tissue generation and offers unique advantages for high-throughput cardiac tissue culture.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling

    Dongsheng Guo, Katelyn Daman ... Charles P Emerson Jr
    iMyoblasts, a novel iPS-derived PAX3 muscle stem cell for gene editing, muscle engraftment, and stem cell therapeutics to treat muscle injury and muscular dystrophies.

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