Multi-level molecular modeling reveals how PROTAC-induced protein structural dynamics of degradation machinery complexes promote ubiquitination processes.

Crystal structures of taxane-tubulin complexes allow the understanding of the interaction of paclitaxel (Taxol) with its cellular target in atomic detail and assess the structural determinants for binding.

Flying squirrels may have originated earlier than previously thought and remained unchanged for almost 12 million years.

A rapamycin-induced proximity assay enables rapid identification of optimal E3 ligases for target protein degradation in living cells, streamlining early-stage proteolysis targeting chimera development.

The X-ray structure of the PaNhaP provides a unique view of substrate-ion binding and release in electroneutral sodium/proton antiporters.

The inward-open and outward-open structures of MjNhaP1 explain the mechanism of electroneutral sodium-proton antiport across the cell membrane.

The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).

A viral heliorhodopsin from Emiliania huxleyi virus 202 (V2HeR3) is a light-activated proton transporter, which has the potential to depolarize the host cells by light, possibly to overcome the host defense mechanisms or to prevent superinfection.

Proton channels are present in reef-building corals and constitute important molecular players that should help understand calcification and the response of these organisms to ocean acidification.

Visualization of the real-time conformational transitions of the human voltage-gated proton channel hHv1 provided novel insights into how voltage and pH gradients modify the dynamic behaviors of channel structures to control proton flow across membrane.