510 results found
    1. Microbiology and Infectious Disease

    Bacteria are a major determinant of Orsay virus transmission and infection in Caenorhabditis elegans

    Brian G Vassallo, Noemie Scheidel ... Dennis H Kim
    Distinct members of the Caenorhabditis elegans microbiota can have widely divergent effects on Orsay virus transmission, such that associated bacteria can effectively determine host susceptibility versus resistance to viral infection.
    1. Ecology
    2. Microbiology and Infectious Disease

    Ecology and evolution of viruses infecting uncultivated SUP05 bacteria as revealed by single-cell- and meta-genomics

    Simon Roux, Alyse K Hawley ... Matthew B Sullivan
    Single-cell amplified genome sequencing uncovers virus-host interactions in uncultivated sulfur-oxidizing bacteria with relevance to coupled biogeochemical cycling in marine oxygen minimum zones.
    1. Ecology
    2. Epidemiology and Global Health

    Exploring factors shaping antibiotic resistance patterns in Streptococcus pneumoniae during the 2020 COVID-19 pandemic

    Aleksandra Kovacevic, David RM Smith ... Lulla Opatowski
    The mathematical modeling approach disentangles the impacts of the COVID-19 pandemic on antibiotic resistance in Streptococcus pneumoniae in the community setting and identifies the three most plausible driving mechanisms responsible for the observed trends in invasive isolates and pneumococcal carriage.
    1. Structural Biology and Molecular Biophysics

    Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability

    Cihan Makbul, Michael Nassal, Bettina Böttcher
    Duck Hepatitis B core protein forms capsids with a slowly folding extension domain which folding competence is important for viral replication.
    1. Microbiology and Infectious Disease

    An Aedes aegypti-associated fungus increases susceptibility to dengue virus by modulating gut trypsin activity

    Yesseinia I Angleró-Rodríguez, Octavio AC Talyuli ... George Dimopoulos
    Talaromyces (Tsp_PR) fungus render Aedes aegypti mosquitoes more susceptible to dengue virus infection through secreted molecules that impair midgut digestive enzyme transcription and activity.
    1. Ecology
    2. Genetics and Genomics

    Viral dark matter and virus–host interactions resolved from publicly available microbial genomes

    Simon Roux, Steven J Hallam ... Matthew B Sullivan
    From public microbial genomes, VirSorter revealed 12,498 viral genome sequences that expand the map of the global virosphere and whose analyses improve understanding of viral taxonomy, evolution and virus-host interactions.
    1. Microbiology and Infectious Disease

    Polysaccharides induce deep-sea Lentisphaerae strains to release chronic bacteriophages

    Chong Wang, Rikuan Zheng ... Chaomin Sun
    Chronic bacteriophages are induced by the supplement of polysaccharide in the deep-sea Lentisphaerae strains, and these bacteriophages potentially reprogram host polysaccharide metabolism through the auxiliary metabolic genes.
    1. Microbiology and Infectious Disease

    Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection

    Mackenzie M Shipley, Vidya Mangala Prasad ... Julie M Overbaugh
    A bnAb derived from a case of HIV superinfection has distinct qualities from other HIV-specific bnAbs, including framework residues that contribute to neutralization breadth and a unique viral escape profile.
    1. Biochemistry and Chemical Biology

    Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection

    Donghyuk Shin, Anshu Bhattacharya ... Ivan Dikic
    A novel class of bacterial OTU deubiquitinases provides insights on the distinct roles of bacterial deubiquitinases in host–pathogen interactions.
    1. Microbiology and Infectious Disease

    Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells

    Siyuan Ding, Shu Zhu ... Harry B Greenberg
    Rotavirus infection induces phosphorylation and proteasomal degradation of MAVS to suppress host antiviral interferon signaling.

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