299 results found
    1. Cell Biology
    2. Physics of Living Systems

    Catalytic growth in a shared enzyme pool ensures robust control of centrosome size

    Deb Sankar Banerjee, Shiladitya Banerjee
    A catalytic growth model in a shared enzyme pool explains robust centrosome size equality and size scaling, offering a unifying model for centrosome maturation dynamics across diverse organisms.
    1. Stem Cells and Regenerative Medicine

    Klp10A, a stem cell centrosome-enriched kinesin, balances asymmetries in Drosophila male germline stem cell division

    Cuie Chen, Mayu Inaba ... Yukiko M Yamashita
    Microtubule-depolymerizing kinesin, Klp10A, prevents overgrowth of the mother centrosome to prevent undesirable asymmetries during asymmetric divisions of Drosophila male germline stem cells.
    1. Cell Biology
    2. Physics of Living Systems

    Stoichiometric interactions explain spindle dynamics and scaling across 100 million years of nematode evolution

    Reza Farhadifar, Che-Hang Yu ... Daniel J Needleman
    Stoichiometric interactions between microtubules and cortical force-generators set spindle size, position and dynamics, and its scaling with cell size in nematode species.
    1. Developmental Biology

    TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23)

    Louise A Stephen, Hasan Tawamie ... Hanno J Bolz
    Mutations in KIAA0586 (TALPID3) cause a severe ciliopathy called Joubert syndrome that affects organ, cell and centrosome polarity.
    1. Developmental Biology

    Loss of ninein interferes with osteoclast formation and causes premature ossification

    Thierry Gilbert, Camille Gorlt ... Andreas Merdes
    It is shown that the absence of the centrosome protein ninein provokes premature ossification during mouse development, due to a defect in the fusion of precursor cells into syncytial osteoclasts.
    1. Cell Biology

    Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates

    Guadalupe Sepulveda, Mark Antkowiak ... Li-En Jao
    During centrosome maturation, pericentrin is delivered to the centrosome co-translationally by a microtubule- and dynein-dependent process, as pericentrin mRNA is undergoing active translation near the centrosome.
    1. Cell Biology
    2. Computational and Systems Biology

    Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

    Peter Jan Hooikaas, Hugo GJ Damstra ... Anna Akhmanova
    Kinesin-4 KIF21B promotes rapid reorientation of the microtubule network during formation of immunological synapse in T cells by acting as a pausing and catastrophe-inducing factor that keeps microtubules short.
    1. Cell Biology
    2. Developmental Biology

    Alstrom syndrome gene is a stem-cell-specific regulator of centriole duplication in the Drosophila testis

    Cuie Chen, Yukiko M Yamashita
    Alms1a is a centrosomal protein that exhibits asymmetric localization between mother and daughter centrosomes in asymmetrically dividing stem cells in Drosophila testis, controlling centriole duplication.
    1. Stem Cells and Regenerative Medicine

    Cell Division: Sibling cell size matters

    Clemens Cabernard
    A motor protein called Klp10A ensures that germline stem cells in male fruit flies divide to produce two sibling cells that are equal in size.
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    1. Cell Biology
    2. Developmental Biology

    Physical association between a novel plasma-membrane structure and centrosome orients cell division

    Takefumi Negishi, Naoyuki Miyazaki ... Naoto Ueno
    A newly discovered membrane structure associates with one of the centrioles and affects two important centrosomal events in epidermal cells – ciliary positioning and spindle orientation – through a physical interaction.

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