387 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cell Cycle: Micromanaging checkpoint proteins

    Andrea Ciliberto, Silke Hauf
    The kinase Mps1, long known to be the 'boss' in mitotic checkpoint signaling, phosphorylates multiple proteins in the checkpoint signaling cascade.
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    1. Cell Biology

    The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness of the spindle assembly checkpoint

    Babhrubahan Roy et al.
    Cell biological and genetic analyses reveal how budding yeast cells optimize Spindle Assembly checkpoint signaling to maximize chromosome segregation accuracy and minimize unnecessary delays in anaphase onset.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    SLAMF6​ deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint

    Emma Hajaj et al.
    SLAMF6 is an inhibitory checkpoint of T cells, the lack of which leads to better tumor control, suggesting a new immunotherapy target.
    1. Immunology and Inflammation

    CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells

    Xiaomei Yuan et al.
    Tissue-resident macrophages sense environmental cues and regulate adaptive immunity via an immune checkpoint molecule CRIg.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

    Floris Foijer et al.
    Chromosomal instability through spindle assembly checkpoint alleviation facilitates malignant transformation of hepatocytes and T-cells in vivo, resulting in cancers with recurrent karyotypes.
    1. Chromosomes and Gene Expression

    SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint

    Sílvia Carvalho et al.
    The involvement of SETD2 in an important DNA repair pathway could explain the high frequency of SETD2 mutations in several cancers and may provide an alternative mechanism to evade the p53-mediated checkpoint.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling

    Zhejian Ji et al.
    The spindle checkpoint kinase Mps1 sequentially phosphorylates multiple substrates to amplify checkpoint signals, making the checkpoint highly dependent on Mps1 function and directly responsive to kinetochore-microtubule attachment.
    1. Cell Biology

    A FRET-based study reveals site-specific regulation of spindle position checkpoint proteins at yeast centrosomes

    Yuliya Gryaznova et al.
    Daughter-cell-associated factors and centrosome-based regulation is important in mitotic exit and spindle position checkpoint control.
    1. Chromosomes and Gene Expression

    Cdc7 activates replication checkpoint by phosphorylating the Chk1-binding domain of Claspin in human cells

    Chi-Chun Yang et al.
    Cdc7 and CK1g1 independently and additively phosphorylate the Chk1-binding domain of claspin to activate replication checkpoint with differential contribution of each kinase in different cell types.
    1. Cell Biology

    Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing

    Margarida Moura et al.
    Inactivation of the master mitotic checkpoint regulator Mps1 by protein phosphatase 1 is required for timely segregation of the genetic material during cell division.

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