Simultaneous voltage and calcium two-photon imaging of Purkinje neuron dendrites in awake mice reveals multiple interplaying mechanisms underlying sensory-evoked dendritic coincidence detection of parallel fiber and climbing fiber input.
William T Redman, Nora S Wolcott ... Michael J Goard
Two-photon imaging through glass microperiscopes allows imaging of the transverse plane of the hippocampus, including all major subfields, in awake behaving mice.
New protein labeling strategies unravel the subcellular distribution of neurotransmitter receptor subunits and voltage-gated ion channels in motion-sensing T4/T5 neurons of the Drosophila visual system.
Christiane Pleuger, Dingding Ai ... Andreas Meinhardt
A strategical positioning of resident immune cells are key in determining a tightly controlled immune environment in the different regions of the mouse epididymis that creates unique spatial milieus for sperm maturation and combatting invading pathogens.
Enric Gutiérrez-Martínez, Susana Benet Garrabé ... Maria F Garcia-Parajo
Advanced imaging methods reveal that Siglec-1 spatial distribution on mature dendritic cells is regulated by components of the actin polymerization machinery impacting on its engagement to HIV-particles and virus sequestration toward virus-containing compartments.
Super-resolution imaging reveals how the skeleton that supports the outer membrane of axons is assembled during development, and provides an explanation for why this structure preferentially forms in axons but rarely in dendrites.
Excitatory synapses that occur further away from the postsynaptic cell soma exhibit greater neurotransmitter release probability, which appears to improve signal transfer fidelity for high-frequency afferent firing.
The receptor EBI2 is essential for correctly positioning CD4+ dendritic cells in the spleen so that they can present blood-borne antigens to T cells and thereby provoke an antibody response.
