464 results found
    1. Cell Biology

    Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells

    Wenyang Li, Jennifer Y Chen ... Alan C Mullen
    A high-throughput small molecule screen defined compounds that inactivate primary human hepatic stellate cells (HSCs) and led to the identification of nanchangmycin, which regulates intracellular Ca2+ levels and the activity of multiple kinases to control HSC fibrotic activity.
    1. Cancer Biology
    2. Immunology and Inflammation

    Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier

    Ngoc Lan Tran, Lorena Maria Ferreira ... Giovanni Sitia
    Continuous perioperative IFNα therapy stimulates hepatic endothelial cells to build up physical vascular barrier that limits tumor cell entry into the liver and promotes long-term antitumor immunity.
    1. Stem Cells and Regenerative Medicine

    Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

    Ece Yildiz, Gaby El Alam ... Kristina Schoonjans
    Chronic fat overload triggers the conversion of quiescent biliary epithelial cells into proliferative progenitors through an E2F-dependent mechanism.
    1. Cell Biology
    2. Immunology and Inflammation

    ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin

    Cristina Cacho-Navas, Carmen López-Pujante ... Jaime Millán
    ICAM-1 engagement controls hepatic cell polarity, but this receptor can also signal without prior leukocyte interaction, thanks to its confinement into apical, microvilli-enriched, bile-canalicular domains and its actin connector EBP50.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

    Takeshi Katsuda, Juntaro Matsuzaki ... Takahiro Ochiya
    Human chemically induced liver progenitors (hCLiPs), which are generated from primary human hepatocytes, exhibit the potential to repopulate injured livers of host mice with efficiency > 90%.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models

    Komal Ramani, Nirmala Mavila ... Eki Seki
    Site-specific phosphorylation of the A-kinase anchoring protein 12 (AKAP12) in hepatic stellate cells modulates its scaffolding function and promotes liver fibrosis.
    1. Immunology and Inflammation
    2. Medicine

    FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis

    Cong Liu, Milena Schönke ... Patrick CN Rensen
    Fibroblast growth factor 21 blocks hepatic lipid influx and accumulation, prevents Kupffer cell activation, and inhibits the formation of hepatic lipid- and scar-associated macrophages, thereby likely inhibiting fibrogenesis in nonalcoholic steatohepatitis in humanized APOE*3-Leiden.CETP mice.
    1. Cell Biology

    Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

    Kyounghee Min, Batuhan Yenilmez ... Michael P Czech
    Stellate cell lactate transporter MCT1 significantly contributes to liver fibrosis through increased collagen 1 protein expression in vitro and in vivo.
    1. Immunology and Inflammation
    2. Medicine

    Complement 3a receptor 1 on macrophages and Kupffer cells is not required for the pathogenesis of metabolic dysfunction-associated steatotic liver disease

    Edwin A Homan, Ankit Gilani ... James C Lo
    Ablation of the G-protein-coupled receptor C3aR1 specifically on macrophages or Kupffer cells does not alter the course of metabolic dysfunction-associated steatotic liver disease in a dietary mouse model.
    1. Cell Biology
    2. Immunology and Inflammation

    HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12 heterodimerization in macrophages

    Wei-Jia Luo, Sung-Liang Yu ... Kang-Yi Su
    Single-cell RNA sequencing reveals HLJ1 as a novel immunomodulator for multicellular pathway of macrophages and NK cells, contributing to organ injury and sepsis death through amplified IL-12/IFN-γ axis.

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