15 results found
    1. Neuroscience

    Effects of fluorescent glutamate indicators on neurotransmitter diffusion and uptake

    Moritz Armbruster et al.
    Fluorescent glutamate indicators distort the time course of neurotransmitter diffusion and uptake by competing with transporters, an important caveat to consider when using iGluSnFR and its analogs.
    1. Neuroscience

    Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons

    Jason D Vevea, Edwin R Chapman
    Knockoff is a tool for researchers who wish to acutely disrupt a membrane protein.
    1. Neuroscience

    Neuron-glia signaling in developing retina mediated by neurotransmitter spillover

    Juliana M Rosa et al.
    Retinal waves are correlated with calcium transients in Müller cells, demonstrating that spontaneous activity encompasses both neuronal and glial networks during a crucial period of retinal development.
    1. Neuroscience

    Flexible motor sequence generation during stereotyped escape responses

    Yuan Wang et al.
    Time-ordered and flexible motor sequences in C.elegans are generated by combining an excitatory feedforward coupling and mutual inhibitions between neurons in different functional modules.
    1. Neuroscience

    Release probability increases towards distal dendrites boosting high-frequency signal transfer in the rodent hippocampus

    Thomas P Jensen et al.
    Excitatory synapses that occur further away from the postsynaptic cell soma exhibit greater neurotransmitter release probability, which appears to improve signal transfer fidelity for high-frequency afferent firing.
    1. Neuroscience

    Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease

    Jeremy F Atherton et al.
    In mouse models of Huntington's disease, the subthalamic nucleus, which suppresses movements, also exhibits impaired glutamate homeostasis, NMDA receptor-dependent mitochondrial oxidant stress, firing disruption, and 30% neuronal loss.
    1. Neuroscience

    Spatiotemporal patterns of neocortical activity around hippocampal sharp-wave ripples

    J Karimi Abadchi et al.
    The hippocampus and neocortex engage in waves of mutual excitation wherein a sharp wave-ripple may occur at any time before, during or after the peak of the hippocampal-neocortical activation.
    1. Neuroscience

    ON selectivity in the Drosophila visual system is a multisynaptic process involving both glutamatergic and GABAergic inhibition

    Sebastian Molina-Obando et al.
    A fundamental visual computation, the establishment of ON selectivity, is established across distributed circuits, allowing for more robust and flexible coding than suggested by core circuit motifs.
    1. Computational and Systems Biology
    2. Neuroscience

    Mapping nonlinear receptive field structure in primate retina at single cone resolution

    Jeremy Freeman et al.
    Multi-electrode recordings and modeling are combined to reveal the transformations of signals from cones to bipolar cells and then to ganglion cells within the primate retina.
    1. Developmental Biology
    2. Neuroscience

    Transverse sinus injections drive robust whole-brain expression of transgenes

    Ali S Hamodi et al.
    A new viral injection method targets the transverse sinuses to achieve robust whole-brain delivery of single or multiple genes in multiple mammalian species early in development.

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