2,300 results found
    1. Cancer Biology
    2. Computational and Systems Biology

    Aspirin’s effect on kinetic parameters of cells contributes to its role in reducing incidence of advanced colorectal adenomas, shown by a multiscale computational study

    Yifan Wang, C Richard Boland ... Natalia L Komarova
    A mathematical model of colorectal cancer initiation shows that a change in cells’ kinetic parameters due to aspirin can account for an observed reduction in advanced adenoma age- incidence in patients treated with aspirin.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea

    Natalie E Hofmann, Stephan Karl ... Ivo Mueller
    Under sustained malaria control in PNG, the incidence of distinct blood-stage infections quantifies heterogeneity in transmission, significantly predicting risk of both P. falciparum and P. vivax malaria episodes at a population and individual scale.
    1. Neuroscience

    Dendritic coincidence detection in Purkinje neurons of awake mice

    Christopher J Roome, Bernd Kuhn
    Simultaneous voltage and calcium two-photon imaging of Purkinje neuron dendrites in awake mice reveals multiple interplaying mechanisms underlying sensory-evoked dendritic coincidence detection of parallel fiber and climbing fiber input.
    1. Epidemiology and Global Health

    Approximating missing epidemiological data for cervical cancer through Footprinting: A case study in India

    Irene Man, Damien Georges ... Iacopo Baussano
    The proposed Footprinting framework enables approximation of missing cervical cancer epidemiological data and derivation of context-specific impact projection of cervical cancer prevention measures, assisting public health decisions on cervical cancer prevention in India and other countries.
    1. Cancer Biology
    2. Epidemiology and Global Health

    Associations of combined phenotypic aging and genetic risk with incident cancer: A prospective cohort study

    Lijun Bian, Zhimin Ma ... Guangfu Jin
    Older PhenoAge was consistently related to an increased risk of incident cancer with adjustment for chronological age and the aging process could be retarded by adherence to a healthy lifestyle.
    1. Epidemiology and Global Health

    Spatio-temporal associations between deforestation and malaria incidence in Lao PDR

    Francois Rerolle, Emily Dantzer ... Adam Bennett
    Deforestation near villages is associated with short-term increases but long-term decreases in malaria incidence in Lao PDR, highlighting the influence of forest-going populations on malaria transmission in the region.
    1. Epidemiology and Global Health

    Associations of age at diagnosis of breast cancer with incident myocardial infarction and heart failure: A prospective cohort study

    Jie Liang, Yang Pan ... Fanfan Zheng
    Younger age at diagnosis of breast cancer was associated with higher risks of incident myocardial infarction and heart failure.
    1. Epidemiology and Global Health

    A modelling approach to estimate the transmissibility of SARS-CoV-2 during periods of high, low, and zero case incidence

    Nick Golding, David J Price ... Freya M Shearer
    A new statistical model for tracking current and potential rates of disease transmission.
    1. Epidemiology and Global Health

    Building resilient cervical cancer prevention through gender-neutral HPV vaccination

    Irene Man, Damien Georges ... Iacopo Baussano
    Shifting from girls-only to gender-neutral HPV vaccination strategy improves the resilience of cervical cancer prevention and enhances progress towards cervical cancer elimination.
    1. Epidemiology and Global Health

    Prediction of diabetic kidney disease risk using machine learning models: A population-based cohort study of Asian adults

    Charumathi Sabanayagam, Feng He ... Ching Yu Cheng
    Integrating machine learning (ML) models with selected features improved the prediction accuracy of diabetic kidney disease compared to traditional logistic regression models using established features, revealing potential new markers and supporting the use of ML techniques in epidemiological studies.

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