Andrew E Worthy, Joanna T Anderson ... Francisco J Alvarez
Major differences among the main spinal V1 inhibitory interneuron subgroups were revealed based on neurogenesis, circuit placement, and motoneuron targeting, and Foxp2-V1 interneurons were identified tightly coupled to limb control.
Neuropeptide Y-expressing interneurons in the spinal dorsal horn have a broad inhibitory role, suppressing pruritogen-evoked itch and reducing behavioural signs of acute, inflammatory, and neuropathic pain.
Thalamic interneurons in the mouse thalamus are often overlooked because of their extremely low numbers, however they are developmentally complex and related to those of larger-brained species.
Yulia Bereshpolova, Xiaojuan Hei ... Harvey A Swadlow
In the visual system, three rules guide the thalamocortical connectivity of cortical fast-spike interneurons and are key to understand the potent and broadly tuned feed-forward inhibition that they generate.
Damiano Gentiletti, Marco de Curtis ... Piotr Suffczynski
Biophysically realistic computational model reveals how inhibitory interneurons initiate paroxysmal discharges and how changes in the ionic concentrations shape electrographic features of human seizures.
Trans-synaptic protein interactions are required for synapse specification and function, and the combination between neuroligin3 and αneurexin1 controls inhibitory synaptic function in a splice isoform- and interneuron-specific manner.
The synaptic structure in mouse V1 is explained by a synergy of homeostatic plasticity in incoming and outgoing synapses of inhibitory interneurons, establishing a stimulus-specific balance of excitation and inhibition.
Cortical interneurons inhibit pyramidal cells to a greater degree when they form synapses with the pyramidal cell body than when they form synapses with dendrites.
Two major subtypes of cortical interneurons, the PV and the SST positive cells, causally contribute to the regulation of large-scale state transitions in the cortex.
Two classes of premotor inhibitory neurons have specific roles in controlling flexor-extensor behaviors in mice, which is the underlying neural mechanism for limb driven movements in terrestrial vertebrates.