42 results found
    1. Medicine
    2. Physics of Living Systems

    Synchronization in renal microcirculation unveiled with high-resolution blood flow imaging

    Dmitry Postnov, Donald J Marsh ... Olga Sosnovtseva
    High-resolution blood flow imaging confirms the presence of large, long-living synchronous clusters in renal microcirculation and reveals how vasoactive drugs affect synchronization properties.
    1. Neuroscience

    Cell type specificity of neurovascular coupling in cerebral cortex

    Hana Uhlirova, Kıvılcım Kılıç ... Anna Devor
    Excitatory and inhibitory cortical neurons drive parallel vasodilatory pathways, while vasoconstriction is mediated exclusively by inhibition acting via Neuropeptide Y binding to Y1 receptors.
    1. Neuroscience

    Cerebral blood flow and cerebrovascular reactivity are preserved in a mouse model of cerebral microvascular amyloidosis

    Leon P Munting, Marc Derieppe ... Louise van der Weerd
    The causal link between capillary amyloid‑β accumulation in the brain and cerebrovascular dysfunction, previously established in the Tg‑SwDI mouse model, is to be mitigated and remains to be fully uncovered.
    1. Cell Biology

    Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance

    Ramesh Chennupati, Angela Wirth ... Stefan Offermanns
    Genetic mouse models identify a critical mechanism of myogenic vasoconstriction and reveal the in vivo function of myogenic autoregulation in protecting from organ overperfusion and in maintaining vascular resistance.
    1. Neuroscience

    Per-ischemic changes in penumbral blood supply and its microscopic distribution

    Nina K. Iversen, Eugenio Gutierréz Jimenéz ... Leif Østergaard
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cell Biology
    2. Physics of Living Systems

    Single-molecule turnover dynamics of actin and membrane coat proteins in clathrin-mediated endocytosis

    Michael M Lacy, David Baddeley, Julien Berro
    The main proteins of clathrin-mediated endocytosis bind and unbind rapidly, continuously turning over about five times during the formation of an endocytic vesicle in yeast.
    1. Chromosomes and Gene Expression

    Post-transcriptional splicing can occur in a slow-moving zone around the gene

    Allison Coté, Aoife O'Farrell ... Arjun Raj
    The existence of a slow-moving zone around the transcription site may unify conflicting models of co-transcriptional versus post-transcriptional mRNA splicing.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Nanoscale architecture and coordination of actin cores within the sealing zone of human osteoclasts

    Marion Portes, Thomas Mangeat ... Renaud Poincloux
    Cutting-edge super-resolution microscopy methods reveal the architecture and dynamics of the sealing zone formed by human osteoclasts and composed of coordinated groups of podosomal cores encircled by adhesion complexes.
    1. Cell Biology

    Cell Adhesion-Dependent Biphasic Axon Outgrowth Elucidated by Femtosecond Laser Impulse

    Sohei Yamada, Kentarou Baba ... Yoichiroh Hosokawa
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Three-dimensional multi-site random access photostimulation (3D-MAP)

    Yi Xue, Laura Waller ... Nicolas Pégard
    A one-photon three-dimensional light sculpture technique has been developed and demonstrated for high spatio-temporal resolution photostimulation and imaging of dozens of neurons in the intact mouse brain in vivo.

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