Joan Isern, Andrés García-García ... Simón Méndez-Ferrer
Developing long bones contain distinct mesenchymal stem-cell populations derived from mesoderm and neural crest, which have specialized functions in skeleton formation and the establishment of the hematopoietic stem-cell niche, respectively.
Comparision of current and fluorescent kinetics from P2X7 receptor mutants labeled with the fluorescent amino acid ANAP suggests that the characteristic P2X7 current facilitation involves changes in channel gating rather than interactions or conformational changes of its intracellular ballast domain.
Adult stem cells sense nearby tissue damage and recruit immune cells to help them direct efforts towards containing a breach in the epithelial barrier.
Joaquín Calatayud, Magnus Neuman ... Martin Rosvall
Similarities in climatic niches of terrestrial vertebrates indicate the Earth's climate regions, which differ among groups and from previous plant-based climate classifications.
Wnt signaling regulates cellular redox in the germline stem cell differentiation niche via a novel regulatory mechanism, thereby controlling germ line stem cell progeny differentiation.
Amir Hossein Kayvanjoo, Iva Splichalova ... Elvira Mass
Identification of distinct yolk sac-derived macrophage subpopulations in the fetal liver reveals their crucial role in shaping the hematopoietic niche, impacting erythropoiesis and granulopoiesis through direct interactions with long-term hematopoietic stem cells.
Interleukin 15-producing microenvironments in the fetal and adult liver foster a type 1 innate lymphoid cell lineage with intrinsic cytotoxicity mediated through cytotoxic granules that are expressed under their steady state, unlike conventional natural killer cells with stimulation-dependent cytotoxicity.
