131 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Potential impact of outpatient stewardship interventions on antibiotic exposures of common bacterial pathogens

    Christine Tedijanto, Yonatan H Grad, Marc Lipsitch
    Antibiotic stewardship in the outpatient setting can substantially reduce exposures of potential pathogens to common antibiotics, and complementary efforts are needed to reduce remaining exposures that occur in 'necessary' contexts.
    1. Medicine

    Exploratory data on the clinical efficacy of monoclonal antibodies against SARS-CoV-2 Omicron variant of concern

    Fulvia Mazzaferri, Massimo Mirandola ... Evelina Tacconelli
    Compared with casirivimab/imdevimab and bamlanivimab/etesevimab, early treatment with sotrovimab seems to reduce the time to sustained recovery among adult outpatients with mild-to-moderate SARS-CoV-2 infection due to Omicron BA.1 and BA.1.1.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The distribution of antibiotic use and its association with antibiotic resistance

    Scott W Olesen, Michael L Barnett ... Yonatan H Grad
    Population-level antibiotic resistance correlates with the breadth of antibiotic use, that is, the proportion of people taking an antibiotic, better than with intensity of use the amount of use among users.
    1. Immunology and Inflammation
    2. Medicine

    Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study

    Zicheng Hu, Kattria van der Ploeg ... Prasanna Jagannathan
    Immune markers measured at the early stage of COVID-19 infection are associated with various clinical outcomes and can be used to predict disease progression, T cell memory, viral shedding, and the antibody response of the COVID-19 patients.
    1. Immunology and Inflammation
    2. Medicine

    Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection

    Noah J Silverstein, Yetao Wang ... Jeremy Luban
    Homeostatic innate lymphoid cell abundance, adjusted for age and sex, correlates inversely with COVID-19 severity in adults and children.
    1. Cancer Biology
    2. Medicine

    Long COVID in cancer patients: preponderance of symptoms in majority of patients over long time period

    Hiba Dagher, Anne-Marie Chaftari ... Issam I Raad
    Long COVID occurred in the majority of cancer patients diagnosed with acute COVID-19 with a preponderance of symptoms (such as fatigue, sleep disturbances, and gastrointestinal symptoms) over a long time period.
    1. Immunology and Inflammation
    2. Medicine

    Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

    Jack Gisby, Candice L Clarke ... James E Peters
    Severe COVID-19 is characterised by a plasma proteomic biomarker signature, indicating innate immune activation, leucocyte–endothelial interactions, and epithelial injury.
    1. Medicine

    Increase in clinically recorded type 2 diabetes after colectomy

    Anders B Jensen, Thorkild IA Sørensen ... Kristine H Allin
    This nationwide register-based study of diabetes risk after colectomy suggests that the left colon contributes to maintenance of glucose homeostasis.
    1. Ecology
    2. Epidemiology and Global Health

    Exploring factors shaping antibiotic resistance patterns in Streptococcus pneumoniae during the 2020 COVID-19 pandemic

    Aleksandra Kovacevic, David RM Smith ... Lulla Opatowski
    The mathematical modeling approach disentangles the impacts of the COVID-19 pandemic on antibiotic resistance in Streptococcus pneumoniae in the community setting and identifies the three most plausible driving mechanisms responsible for the observed trends in invasive isolates and pneumococcal carriage.
    1. Microbiology and Infectious Disease

    Quantity of SARS-CoV-2 RNA copies exhaled per minute during natural breathing over the course of COVID-19 infection

    Gregory Lane, Guangyu Zhou ... Christina Zelano
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete

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