60 results found
    1. Developmental Biology

    Neuronal sources of hedgehog modulate neurogenesis in the adult planarian brain

    Ko W Currie et al.
    Planarian brain neurons modulate their turnover by signaling to nearby stem cells.
    1. Stem Cells and Regenerative Medicine

    A mex3 homolog is required for differentiation during planarian stem cell lineage development

    Shu Jun Zhu et al.
    The planarian mex3-1 gene is required for non-stem cell fates and suppresses a stem cell fate in differentiating cells.
    1. Stem Cells and Regenerative Medicine

    Positional information specifies the site of organ regeneration and not tissue maintenance in planarians

    Eric M Hill, Christian P Petersen
    Homeostatic tissue maintenance can occur at locations distinct from the target sites of organ regeneration planarians.
    1. Developmental Biology

    Hedgehog signaling regulates gene expression in planarian glia

    Irving E Wang et al.
    Hedgehog signaling plays a role in regulating glia gene expression in planarians, pointing to a candidate ancestral and broadly used role for the Hedgehog pathway.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    A functional genomics screen in planarians reveals regulators of whole-brain regeneration

    Rachel H Roberts-Galbraith et al.
    A gene expression-guided functional screen identifies factors and cell types that regulate diverse aspects of neural regeneration in planarians.
    1. Physics of Living Systems

    Body size-dependent energy storage causes Kleiber’s law scaling of the metabolic rate in planarians

    Albert Thommen et al.
    A combination of experimental and theoretical analysis identifies body size-dependent energy storage as the physiological cause of 3/4-power law scaling of the metabolic rate in planarians.
    1. Stem Cells and Regenerative Medicine

    Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

    Jordi Solana et al.
    A conserved alternative splicing program is specific to planarian stem cells and is controlled by the highly conserved splicing factors CELF and MBNL; therefore, this mode of regulating stem cells is likely ancestral to all animals.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Light-induced depigmentation in planarians models the pathophysiology of acute porphyrias

    Bradford M Stubenhaus et al.
    Physiological porphyrin biosynthesis causes photosensitivity in fasted planarians, providing an experimentally tractable animal model of acute porphyrias.
    1. Developmental Biology

    Two FGFRL-Wnt circuits organize the planarian anteroposterior axis

    M Lucila Scimone et al.
    Single-cell RNA sequencing identifies an adult regional gene expression map in planarian muscle that includes two FGFRL-Wnt circuits controlling head and trunk tissue pattern.
    1. Stem Cells and Regenerative Medicine

    Cystic Kidney Disease: Planarian ‘kidneys’ go with the flow

    Melanie Issigonis, Phillip A Newmark
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