346 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence

    Kevin G Hicks, Scott P Delbecq ... Samuel I Miller
    Receptor recognition of antimicrobial peptides is important for Salmonellae to survive inside macrophages and cause disease.
    1. Microbiology and Infectious Disease

    Dynamics of macrophage polarization support Salmonella persistence in a whole living organism

    Jade Leiba, Tamara Sipka ... Mai E Nguyen-Chi
    Real-time visualization of Salmonella enterica and polarized macrophage interaction in the living host identifies an anti-inflammatory, pro-regenerative, and motionless macrophage subset as a survival niche during persistent infection.
    1. Microbiology and Infectious Disease

    The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing

    Stuti K Desai, Ricksen S Winardhi ... Linda J Kenney
    A response regulator acquired via lateral gene transfer has rewired an ancestral genetic circuitry and regulates alternative pathogenic lifestyles.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

    Megan E Carey, Zoe A Dyson ... Global Typhoid Genomics Consortium Group Authorship
    An analysis of the largest Salmonella Typhi genome collection to date (n=13,000) provides an updated overview of global genome diversity and antimicrobial resistance trends over time to inform public health action.
    1. Medicine

    The zinc transporter Slc30a1 (ZnT1) in macrophages plays a protective role against attenuated Salmonella

    Pinanong Na-Phatthalung, Shumin Sun ... Fudi Wang
    Zinc transporter Slc30a1 mediates antibacterial defense in macrophages.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Rapid geographical source attribution of Salmonella enterica serovar Enteritidis genomes using hierarchical machine learning

    Sion C Bayliss, Rebecca K Locke ... Lauren A Cowley
    Application of hierarchical machine learning to the geographical source attribution of Salmonella enteritidis indicates high utility for the rapid translation of raw pathogen genome sequencing data into accurate and actionable information for disease management in public health.
    1. Microbiology and Infectious Disease

    Avian-specific Salmonella transition to endemicity is accompanied by localized resistome and mobilome interaction

    Chenghao Jia, Chenghu Huang ... Min Yue
    Newly produced genomic data, as well as available datasets, reveal the pathogen's global transmission history along with the live poultry trade and pinpoint mobile element-driven local Salmonella adaptation.
    1. Cell Biology

    Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

    Yajun Zhai, Peiyi Liu ... Gongzheng Hu
    The combination therapy of colistin, artesunate, and EDTA could serve as a promising approach to combat colistin-resistant Salmonella infections by disrupting bacterial membranes, collapsing proton motive force, and increasing reactive oxygen species levels.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A pH-sensitive switch activates virulence in Salmonella

    Dasvit Shetty, Linda J Kenney
    A single conserved residue – histidine 12 – confers pH-sensitive DNA binding to the Salmonella Typhimurium SPI-2 transcriptional regulator SsrB, thereby regulating Salmonella virulence.
    1. Microbiology and Infectious Disease

    Structural basis of host recognition and biofilm formation by Salmonella Saf pili

    Longhui Zeng, Li Zhang ... Guoyu Meng
    SafDAA-SafDAA structure and functional characterizations reveal a pili-mediated inter-cellular oligomerization mechanism for bacterial aggregation and biofilm formation in Salmonella enterica.

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