370 results found
    1. Neuroscience

    Experience transforms crossmodal object representations in the anterior temporal lobes

    Aedan Yue Li, Natalia Ladyka-Wojcik ... Morgan D Barense
    Anterior temporal lobe structures differentiated learned from non-learned crossmodal objects, evidence of integrated crossmodal object representations.
    1. Neuroscience

    Topographic gradients of intrinsic dynamics across neocortex

    Golia Shafiei, Ross D Markello ... Bratislav Misic
    Intrinsic dynamics are shaped by the intersection of molecular, microstructural, connectomic, and activation gradients.
    1. Computational and Systems Biology

    Variation in the modality of a yeast signaling pathway is mediated by a single regulator

    Julius Palme, Jue Wang, Michael Springer
    Yeast cells can tune the modality of a nutrient response on physiological and evolutionary timescales by adapting the expression and sequence of a sensor protein.
    1. Neuroscience

    Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions

    Marija Markicevic, Oliver Sturman ... Nicole Wenderoth
    The structural characteristics of a circuit and its hierarchical dimensions are shown to influence regional time-series dynamics after targeted cellular-level manipulations.
    1. Neuroscience

    Brain structure and function link to variation in biobehavioral dimensions across the psychopathological continuum

    Jasper van Oort, Alberto Llera ... Philip FP van Eijndhoven
    The multimodal linked independent component analysis promotes a more integrative understanding of transdiagnostic mechanisms of psychopathology.
    1. Medicine
    2. Neuroscience

    Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study

    Peter R Millar, Brian A Gordon ... Beau M Ances
    Machine learning-based models of brain age using distinct MRI modalities (structural MRI and functional connectivity) capture complementary signals related to healthy age differences and capture unique patterns related to Alzheimer disease, including stages of disease progression, biomarkers, and cognition.
    1. Computational and Systems Biology
    2. Neuroscience

    Shared and modality-specific brain regions that mediate auditory and visual word comprehension

    Anne Keitel, Joachim Gross, Christoph Kayser
    The comprehension of acoustic and visual speech depends on modality-specific pathways in the brain, which explains why auditory speech abilities and lip reading are not associated in typical adults.
    1. Neuroscience

    Cerebral chemoarchitecture shares organizational traits with brain structure and function

    Benjamin Hänisch, Justine Y Hansen ... Sofie Louise Valk
    Dimensionality reduction techniques reveal how the organization of neurotransmitter receptor and transporter co-expression in the human brain may bridge the gap between brain structure and function.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV

    Tongcui Ma, Matthew McGregor ... Nadia R Roan
    Glycans are remodeled by HIV and are determinants of CD4+ T cell susceptibility to HIV infection.
    1. Neuroscience

    Principles of operation of a cerebellar learning circuit

    David J Herzfeld, Nathan J Hall ... Stephen G Lisberger
    Quantitative analysis of behavior coupled with computational modeling reveal the set of circuit-level principles that underlie cerebellar-dependent motor learning in smooth pursuit eye movements of monkeys across timescales.

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