Local sensory signals in visual and frontal cortex play a causal role in task performance, while widespread dorsal cortical signals correlating with movement reflect processes that do not.

Widefield fluorescence from the brain arises from greater depth and area than typically appreciated and is usually a weighted average across cortical columns and often more than one cortical area.

The link between the activity of large populations of cortical neurons and single neuron responses is examined in primates using a new optical-genetic method.

TRUST, as a rapid and fully automated whole-organ imaging technique, enables high-resolution multicolor 3D imaging at low cost by using a UV-LED for widefield illumination and a color camera while relieving researchers from lengthy and laborious tissue processing protocols.

A new methodology and protocol use automated brain imaging and task training technology to probe links between behavior and mouse cortical circuits.

A novel single-objective light-sheet microscope with unparalleled spatiotemporal resolution enables imaging and optical manipulation of diverse biological specimens and processes.

Procedures were developed to perform mesoscale 2-photon Ca²⁺ imaging simultaneously from all of mouse dorsolateral neocortex, facilitating identification of widespread neural ensembles with activity related to diverse aspects of behavior.

Simultaneous optogenetic stimulation and calcium imaging in V1 of behaving macaques reveals that low-power optostimulation can substitute a visual mask and significantly reduce perceptual and neural detection sensitivities.

An adenylyl cyclase isoform is shown to dynamically traffic to endosomes after activation by G protein in mammalian cells, contributing to cellular cAMP signaling by internalized GPCRs.

Three-dimensional fluorescence imaging of microbial eukaryotes in environmental samples allows accurate automated taxonomic profiling and quantitative data about ultrastructures and interactions of organisms.