Browse our latest Biochemistry and Chemical Biology articles

A prominent model for the structural organisation of the Tat (twin-arginine translocase) protein transport system fails live cell tests.

Biochemical data demonstrate an unexpected and critical function for the enigmatic Mcm10 protein in helping the eukaryotic CMG helicase/replisome bypass roadblocks on the DNA that may also explain Mcm10 function at origins of replication.

The placement of single methyl groups at certain positions in the sequence of small model transmembrane proteins consisting solely of leucines and isoleucines can modulate highly specific, productive interactions with the transmembrane domain of the erythropoietin receptor.

Size threshold and suprastructure formation are key parameters that control the infective potential of amyloid fibrils as prion particles.

Efficient targeting of membrane proteins from the endoplasmic reticulum (ER) to the inner nuclear membrane depends on GTP hydrolysis by Atlastin GTPases and their function in maintaining an interconnected topology of the ER network.

Respiratory activity and inner membrane organisation of mitochondria from Drosophila melanogaster break down during ageing, but mouse heart mitochondria appear to be protected against age-related damage.

Channel characteristics of the presequence translocation pore have a direct impact on protein import into the mitochondrial matrix.

An unbiased chemical screen identifies the AAA+ membrane metalloprotease FtsH1 as a novel apicoplast biogenesis factor and druggable antimalarial target.

Signal-peptide cleavage of HIV-1 envelope glycoprotein is delayed because of alpha-helical structure covering the cleavage site, effecting early cleavage alters the folding pathway and resulting in localized misfolding and reduced viral fitness.

Yeast extracts recapitulate a quality-control pathway dedicated to rescuing stalled ribosomes, providing unexpected insights into a noncanonical elongation reaction and the fate of incompletely synthesized proteins.