Browse our latest Biochemistry and Chemical Biology articles

Page 146 of 173
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A vocabulary of ancient peptides at the origin of folded proteins

    Vikram Alva, Johannes Söding, Andrei N Lupas
    A comparative study of modern proteins identifies 40 fragments that may represent the observable remnants of a primordial RNA-peptide world.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation

    Andreu Viader, Daisuke Ogasawara ... Benjamin F Cravatt
    Cell-specific pathways regulate lipid transmitters and neuroinflammation in the brain.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system

    Daichao Xu, Bing Shan ... Junying Yuan
    Akt can regulate the ubiquitin-proteasome system by mediating phosphorylation and activation of USP14, which may have implications in the control of global proteostasis by growth factors and in tumorigenesis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response

    Xing-Huang Gao, Dawid Krokowski ... Maria Hatzoglou
    ATF4, the master regulator of transcription during the Integrated Stress Response (ISR), causes global changes in cysteine sulfhydration of proteins and this event causes cellular metabolic reprogramming.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli

    Christina M Zimanyi, Percival Yang-Ting Chen ... Catherine L Drennan
    Substrate and effector bound structures of a bacterial ribonucleotide reductase reveal the molecular basis by which substrate preference is modulated by a distal site on the enzyme.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Blue light-induced LOV domain dimerization enhances the affinity of Aureochrome 1a for its target DNA sequence

    Udo Heintz, Ilme Schlichting
    Light absorption by the algal transcription factor Aureochrome 1a causes dimerization at the light-oxygen-voltage (LOV) sensing domain, which has implications for the design of synthetic photoreceptors for optogenetics.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Protein flexibility is required for vesicle tethering at the Golgi

    Pak-yan Patricia Cheung, Charles Limouse ... Suzanne R Pfeffer
    Atomic force microscopy reveals a floppy, dimeric, coiled coil Golgin structure that captures transport vesicles via splayed, N-terminal ends at the Golgi complex.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

    Min Zhang, Samuel J Kenny ... Randy Schekman
    Reconstitution of interleukin-1β secretion in non-macrophage cells implicates how this pro-inflammatory cytokine enters into the unconventional pathway of secretion through autophagy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

    Feiran Lu, Qiren Liang ... Michael S Brown
    A nanomolar inhibitor of cholesterol transport out of endosomes/lysosomes can be crosslinked to the “sterol-sensing domain” of NPC1, which implicates this domain in the transmembrane transport of cholesterol.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Resolving dual binding conformations of cellulosome cohesin-dockerin complexes using single-molecule force spectroscopy

    Markus A Jobst, Lukas F Milles ... Michael A Nash
    A single-molecule approach is able to discriminate the redundant binding conformations of cellulosomal dockerin based on differences in their mechanical properties.