A toxin produced by the bacterium Bordetella pertussis preferentially binds to non-activated integrin complement receptor 3 outside of its ligand-binding I-domain and efficiently blocks downstream signaling of the integrin through elevation of cytosolic cAMP.
Rupa Banerjee, Christina Gladkova ... Dejana Mokranjac
Two domains of the peripheral membrane protein Tim44 interact with two different sectors of a translocase to coordinate the translocation of proteins across the inner mitochondrial membrane.
Marina Theodosiou, Moritz Widmaier ... Reinhard Fässler
Kindlin-2 co-operates with talin to activate fibronectin-binding integrins on fibroblasts and subsequently induces cell spreading by recruiting paxillin to small, peripheral nascent adhesions.
A new method for developing biosensors from ligand binding domains that have concentration-dependent and selective responses to small molecules in yeast, mammalian cells and plants.
Jasper J Visser, Yolanda Cheng ... Woj M Wojtowicz
An integrated approach for studying laminar organization in the developing mouse retina identifies two families of extracellular recognition proteins that mediate neuronal subtype-specific recognition.
Structures of the death domain of the p75 neurotrophin receptor in complex with downstream effectors show how competitive protein-protein interactions orchestrate the hierarchical activation of downstream pathways in non-catalytic receptors.
Attaching a molecule of adenosine mono-phosphate (AMP) to the BiP protein at threonine 518 regulates its chaperone activity in the endoplasmic reticulum.
