Browse our latest Biochemistry and Chemical Biology articles

Proximity labeling combined with mass spectrometry enables to map the proteasome proximal proteome in cells and mouse tissues.

The metabolite 2-hydroxybutyrate is an important aspect of exhaustion which leads to increased capacity in the branched chain amino acid degradation pathway.

Senescent cells release an arachidonic acid-derived electrophilic oxylipin that inhibits myoblast differentiation by covalent modification and activation of HRas.

First high-resolution structure of HGSNAT-acetyl-CoA complex, that describes the architecture of a novel transmembrane N-acetyltransferase fold and provides a molecular basis for MPS IIIC causing mutation induced destabilization of HGSNAT.

Elucidating the 1-naphthylamine degradation pathway in Pseudomonas sp. strain JS3066 and analyzing the catalytic mechanism of the 1-naphthylamine glutamine synthetase deepens the understanding of microbial degradation of polycyclic aromatic amines.

The generation of phosphoinositide 3,4,5-trisphosphate causes an increase in the number of TRPV1 ion channels and insulin receptors in the plasma membrane.

High glucose levels promote CTSL maturation and translocation from the endoplasmic reticulum to the lysosome via the ER-Golgi-lysosome axis.

A new genetically encoded sensor robustly detects exogenously applied PAC1R ligands in vitro, ex vivo, and in vivo (in zebrafishes and mice) serving as a useful resource for probing PAC1R functions.

In crystallo observation of HNH family I-PpoI nuclease cleaving DNA suggests that one divalent metal ion and a histidine are required for catalysis.