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    1. Biochemistry and Chemical Biology

    The membrane domains of mammalian adenylyl cyclases are lipid receptors

    Marius Landau, Sherif Elsabbagh ... Joachim E Schultz
    The dodecahelical membrane anchors of mammalian adenylyl cyclase isoforms are receptors for unsaturated free fatty acids and, as a tonic signal, enhance or attenuate GPCR/Gsα-stimulated cyclic AMP formation.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Determining the off-target activity of antibiotics and novel translation initiation sites in mitochondria

    James Marks, Emma Young, Markus Hafner
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Biochemistry and Chemical Biology
    2. Medicine

    Increased bone inflammation in type 2 diabetes and obesity correlates with Wnt signaling downregulation and reduced bone strength

    Giulia Leanza, Malak Faraj ... Nicola Napoli
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    The chromokinesin Kid (KIF22) forms a homodimer, moves processively along microtubules and transports double-strand DNA

    Shinsuke Niwa, Natsuki Furusaki ... Kyoko Chiba
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Disordered proteins interact with the chemical environment to tune their protective function during drying

    Shraddha KC, Kenny H Nguyen ... Thomas C Boothby
    The ability of intrinsically disordered proteins to protect sensitive enzymes during drying can be tuned through interactions with cosolutes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8

    Amrita Rai, Petra Janning ... Roger S Goody
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology

    Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785

    Shan Zhang, Robyn Stix ... José D Faraldo-Gómez
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    Proteomic and functional comparison between human induced and embryonic stem cells

    Alejandro J Brenes, Eva Griesser ... Angus I Lamond
    Human induced pluripotent stem cells and embryonic stem cells express a similar set of proteins, but the levels of cytoplasmic and mitochondrial proteins vary, with concomitant effects on phenotypes including transport and mitochondrial function.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Isobaric crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and complexes

    Jie Luo, Jeff Ranish
    A novel pair of isobaric crosslinking reagents is described, which allow relative quantification of crosslinker-modified peptides during mass spectrometry analysis for comparative structural studies of proteins and protein complexes.
    1. Biochemistry and Chemical Biology

    Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays

    Jonathan G Van Vranken, Jiaming Li ... Devin K Schweppe
    An approachable framework for the scalable implementation of proteome-wide thermal shift assays to assess drug mechanisms of action.
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