Browse our latest Biochemistry and Chemical Biology articles

Page 15 of 168
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    A mitochondrial carrier transports glycolytic intermediates to link cytosolic and mitochondrial glycolysis in the human gut parasite Blastocystis

    Eva Pyrihová, Martin S King ... Edmund RS Kunji
    Stramenopiles are unusual, because the pay-off phase of glycolysis occurs in mitochondria rather than the cytosol and the identified mitochondrial carrier links the two parts by transporting glycolytic intermediates.
    1. Biochemistry and Chemical Biology

    Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309

    Zheng Ruan, Junuk Lee ... Wei Lü
    A comprehensive analysis questioned the prevailing views of Src-mediated hPANX1 phosphorylation at Tyr199 and Tyr309.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Remodeling of skeletal muscle myosin metabolic states in hibernating mammals

    Christopher TA Lewis, Elise G Melhedegaard ... Julien Ochala
    During hibernation, animals remodel the structure of their relaxed muscle via a protein called myosin and this enables vast temperature changes.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Deciphering the chemical language of inbred and wild mouse conspecific scents

    Maximilian Nagel, Marco Niestroj ... Marc Spehr
    Parallel chemical and physiological profiling of conspecific chemosensory communication in mice identifies both common and unique strategies for vomeronasal signaling of sex and strain.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Caenorhabditis elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA

    Claudia D Consalvo, Adedeji M Aderounmu ... Brenda L Bass
    Biochemical and structural analyses unravel how two RIG-I-like helicases function together to promote antiviral defense and illustrates the diverse ways innate immunity evolved.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors

    Damien M Rasmussen, Manny M Semonis ... Nicholas M Levinson
    A comprehensive allosteric model describes how inhibitors can activate rather than inhibit a target kinase by selectively driving formation of kinase dimers with one inhibited and one activated subunit.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Non-autonomous cell redox-pairs dictate niche homeostasis in multi-lineage stem populations

    Olivia Majhi, Aishwarya Chhatre ... Devanjan Sinha
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    MEMO1 binds iron and modulates iron homeostasis in cancer cells

    Natalia Dolgova, Eva-Maria E Uhlemann ... Oleg Y Dmitriev
    Cancer metastasis modulator MEMO1 binds iron and is involved in regulating iron homeostasis in cancer cells.
    1. Biochemistry and Chemical Biology

    Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

    Benjamin R Duewell, Naomi E Wilson ... Scott D Hansen
    Single molecule reconstitution of PI3Kβ synergistic activation reveals mechanism for rapid PI(3,4,5)P3 production during immune cell signaling.