Browse our latest Biochemistry and Chemical Biology articles

Enzyme tethering of promiscuous biotinylators to the cell surface allows for more rapid and efficient comparative surface proteomic analysis of cells and extracellular vesicles.

AMDHD2 restricts the activity of the essential hexosamine pathway in mouse embryonic stem cells where GFPT2/GFAT2 instead of the common paralog GFPT1/GFAT1 controls metabolite entry.

Structures of PKA in complex with wild type and mutant phospholamban show a mechanism underlying familial dilated cardiomyopathy.

Computer simulations explore the experimentally unknown S-protein structures, revealing novel drug binding sites.

Malaria parasites target a polyprenyl synthase enzyme to the apicoplast organelle and require its activity to produce long-chain linear isoprenoids necessary for apicoplast biogenesis.

Factor Xa and thrombin cleavage activate SARS-CoV-2 spike, widening the scope of host proteases involved in coronavirus entry and demonstrating the potential for dual anticoagulant/antiviral drugs.

Affinity measurements of microRNA sites representing >1000 different pairing architectures reveal that two binding modes can mediate pairing to the microRNA 3′ region, and that microRNA G and oligo(G/C) residues are most impactful.

All steps of a viroid-like replication cycle can be catalyzed by RNA alone.

Mitochondrial metabolic fluxes display a subcellular spatial gradient within a single mouse oocyte, and the fluxes are not controlled by nutrient supply or energy demand of the cell, but by the intrinsic rates of mitochondrial respiration.

The X-ray crystal structure of the unusual carbon–carbon bond-forming biosynthetic enzyme CylK reveals a unique biochemical strategy for selective alkyl halide activation and substitution.