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    1. Computational and Systems Biology
    2. Cancer Biology

    Computational Engineering of a Therapeutic Antibody to Inhibit Multiple Mutants of HER2 Without Compromising Inhibition of the Canonical HER2

    Sapir Peled, Julia Guez-Haddad ... Yanay Ofran
    Revised
    Reviewed Preprint v2
    Updated
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    1. Cancer Biology

    Dual targeting of histone deacetylases and MYC as potential treatment strategy for H3-K27M pediatric gliomas

    Danielle Algranati, Roni Oren ... Efrat Shema
    Combined inhibition of oncogenic and epigenetic pathways results in a substantial decrease in the viability and growth of H3-K27M pediatric glioma models.
    1. Cancer Biology
    2. Cell Biology

    A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo

    Alex Weiss, Cassandra D'Amata ... Madeline N Hayes
    Modeling glioblastoma using expression of relevant human oncogenes in syngeneic zebrafish offers a powerful platform for current and future biological discovery, diagnostics, and therapeutic testing in an intact tumor microenvironment.
    1. Cancer Biology
    2. Cell Biology

    Cancer: Modeling glioblastoma

    Ian Lorimer
    Establishing a zebrafish model of a deadly type of brain tumor highlights the role of the immune system in the early stages of the disease.
    Version of Record
    Insight
    1. Cancer Biology

    YAP/TAZ enhances P-body formation to promote tumorigenesis

    Xia Shen, Xiang Peng ... Chen-Ying Liu
    P-body is a new downstream effector of YAP/TAZ for tumorigenesis and tumor progression, suggesting disruption of P-bodies as a potential therapeutic strategy for tumors with active YAP.
    1. Cancer Biology

    Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

    Megan E Patton, Sherwin Kelekar ... Sayeepriyadarshini Anakk
    Not revised
    Reviewed Preprint v1
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    • Solid
    1. Cancer Biology

    Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

    Pirunthan Perampalam, James I MacDonald ... Frederick A Dick
    Extending the period of remission for cancer patients requires new knowledge of dormant, residual disease and Netrin signaling contributes to the survival of dormant cells in ovarian cancer.
    1. Cancer Biology

    Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

    Youyou Zhang, Mu Xu ... Lin Zhang
    Not revised
    Reviewed Preprint v1
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    1. Chromosomes and Gene Expression
    2. Cancer Biology

    The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

    Ariunaa Bayanjargal, Cenny Taslim ... Emily R Theisen
    Revised
    Reviewed Preprint v2
    Updated
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    • Solid
    1. Cancer Biology
    2. Cell Biology

    Emerging role of oncogenic ß-catenin in exosome biogenesis as a driver of immune escape in hepatocellular carcinoma

    Camille Dantzer, Justine Vaché ... Violaine Moreau
    Findings identify a new link between oncogenic ß-catenin and exosome biogenesis, which may serve as an important nodal point in the immune escape of hepatocellular carcinoma.
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