Tristan Gicquel, Fabio Marchiano ... Alice Carrier
Pancreatic cancer-associated muscle atrophy is characterized by strong mitochondrial metabolic defects that are not limited to carbohydrate, protein, and redox metabolism, but also concern lipid and nucleic acid metabolisms.
The new cancer treatment strategy reduces the volume of mouse cutaneous squamous cell carcinoma and reverses the expression of tumor marker proteins by stimulating the production of serum-based antibodies.
Alexandra Urbancokova, Terezie Hornofova ... Pavla Vasicova
Chemotherapeutics altering DNA topology evoke RNA polymerase I inhibition, rDNA damage and consequent formation of PNAs that segregate persistent rDNA lesions from the active nucleolus, with implications for rDNA maintenance and design of new cancer treatment strategies targeting rDNA repair.
Aurélie Anne-Gaëlle Gabriel, Julien Racle ... David Gfeller
EPIC-ATAC accurately quantifies cell-type heterogeneity in tumor bulk ATAC-Seq samples using reliable cell-type specific chromatin accessibility markers for the major cell types found in tumor microenvironments.
Akashdip Singh, Alberto Miranda Bedate ... Linde Meyaard
A bioinformatics pipeline describes 390 putative, novel inhibitory receptors, to facilitate targeted therapeutic strategies for diverse immune cell types in cancer therapy.
CUT-Tag is used to identify super-enhancers (SEs) for the first time in gastric cancer, and the mRNA decay mechanism activated by SE-driven ZFP36L1 in infiltrative gastric cancer along with innovative experimental evidence demonstrating SPI1/ZFP36L1/HDAC3/PD-L1 signaling axis are presented.
