Browse our latest Cancer Biology articles

Mice studies show that the 'just-right' balance optimal for BRAF^V600E-induced cecal tumor formation can be achieved through FAK alteration.

A computational method based on optimal transport enables state-of-the-art alignment between untargeted metabolomic studies and is evaluated on cord blood and cancer datasets.

PPM1D-mutant leukemia cells exhibit a dysregulated redox landscape, a diminished response to oxidative stress, and rely on SOD1 for their survival.

An in vivo reporter of TGFb signaling in zebrafish reveals that melanoma cells undergoing chronic TGFb signaling up-regulate extracellular matrix genes, down-regulate IFN, and are preferentially phagocytosed by macrophages compared to non-TGFb responsive melanoma cells.

Scaffolding protein RAPSYN can exert its NEDD8 E3 ligase activity to neddylate and stabilize oncogenic BCR-ABL by competing proteasomal degradation in Ph⁺ leukemia.

DUX4 expression is a common feature of metastatic tumors, where it is significantly associated with immune cell exclusion, decreased objective response to immune checkpoint blockade, and reduced patient survival.

A novel role of the mitochondrial BK_Ca channel involves the metabolic reprogramming of breast cancer cells, facilitating their unrestricted proliferation and O₂-independence, which is also of potential clinical relevance.

Chromosomal instability induced in solid tumors can combine with macrophages that are made highly phagocytic to thereby initiate elimination of and immunity against poorly immunogenic tumors in immunocompetent mice.

Assessing metabolites in renal cell carcinoma and kidney tissue suggests cancers adapt rather than dictate nutrient availability.